biostudies-literatureMerlo DFNational Institute for Health Research (NIHR)193-200https://www.ebi.ac.uk/biostudies/studies/S-EPMC3914866biostudies-literatureUnknown122(2)<h4>Background</h4>Leukemia incidence has increased in recent decades among European children, suggesting that early-life environmental exposures play an important role in disease development.<h4>Objectives</h4>We investigated the hypothesis that childhood susceptibility may increase as a result of in utero exposure to carcinogens and hormonally acting factors. Using cord blood samples from the NewGeneris cohort, we examined associations between a range of biomarkers of carcinogen exposure and hormonally acting factors with micronuclei (MN) frequency as a proxy measure of cancer risk. Associations with gene expression and genotype were also explored.<h4>Methods</h4>DNA and protein adducts, gene expression profiles, circulating hormonally acting factors, and GWAS (genome-wide association stEnvironmental health perspectivesMicronuclei in cord blood lymphocytes and associations with biomarkers of exposure to carcinogens and hormonally active factors, gene polymorphisms, and gene expression: the NewGeneris cohort.PMC3914866RP-PG-0407-10044Agramunt SBrady NJNewGeneris ConsortiumChatzi LFthenou EBesselink HHemminki KStagi EWright JSingh RGallo FVande Loock KGodschalk RWKleinjans JCSegerback DNomark ESchoket BSunyer JTornqvist MChen BNielsen JKvan Schooten FJFontana VForsti AMijal RAnna LFleming Svon Stedingk HGmuender HNygaard UCvan Delft JHLukacs VKnudsen LERydberg PGeorgiadis PKyrtopoulos SADecordier IBotsivali MMarcos RHardie LJKogevinas MKovacs KPedersen MCeppi MLovik MKirsch-Volders MHochstenbach KGranum BMerlo DFAnderson DFarmer PBvan Loveren HfalseMicronuclei in cord blood lymphocytes and associations with biomarkers of exposure to carcinogens and hormonally active factors, gene polymorphisms, and gene expression: the NewGeneris cohort.<h4>Background</h4>Leukemia incidence has increased in recent decades among European children, suggesting that early-life environmental exposures play an important role in disease development.<h4>Objectives</h4>We investigated the hypothesis that childhood susceptibility may increase as a result of in utero exposure to carcinogens and hormonally acting factors. Using cord blood samples from the NewGeneris cohort, we examined associations between a range of biomarkers of carcinogen exposure and hormonally acting factors with micronuclei (MN) frequency as a proxy measure of cancer risk. Associations with gene expression and genotype were also explored.<h4>Methods</h4>DNA and protein adducts, gene expression profiles, circulating hormonally acting factors, and GWAS (genome-wide association st2014-01-01T00:00:00Z2014 Feb2026-04-16T09:04:07.684Z2026-04-07T14:07:24.57ZS-EPMC39148662425247210.1289/ehp.1206324