{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Vermijlen D"],"funding":["Wellcome Trust"],"pagination":["4304-14"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3915340"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["178(7)"],"pubmed_abstract":["Human Vgamma9/Vdelta2 T cells comprise a small population of peripheral blood T cells that in many infectious diseases respond to the microbial metabolite, (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate (HMB-PP), expanding to up to 50% of CD3(+) cells. This \"transitional response,\" occurring temporally between the rapid innate and slower adaptive response, is widely viewed as proinflammatory and/or cytolytic. However, increasing evidence that different cytokines drive widely different effector functions in alphabeta T cells provoked us to apply cDNA microarrays to explore the potential pleiotropy of HMB-PP-activated Vgamma9/Vdelta2 T cells. The data and accompanying validations show that the related cytokines, IL-2, IL-4, or IL-21, each drive proliferation and comparable CD69 up-regulatio"],"journal":["Journal of immunology (Baltimore, Md. : 1950)"],"pubmed_title":["Distinct cytokine-driven responses of activated blood gammadelta T cells: insights into unconventional T cell pleiotropy."],"pmcid":["PMC3915340"],"funding_grant_id":["071534"],"pubmed_authors":["Hayday AC","Langford C","Eberl M","Ellis P","Jomaa H","Klein A","Vermijlen D","Willimann K","Engel R"],"additional_accession":[]},"is_claimable":false,"name":"Distinct cytokine-driven responses of activated blood gammadelta T cells: insights into unconventional T cell pleiotropy.","description":"Human Vgamma9/Vdelta2 T cells comprise a small population of peripheral blood T cells that in many infectious diseases respond to the microbial metabolite, (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate (HMB-PP), expanding to up to 50% of CD3(+) cells. This \"transitional response,\" occurring temporally between the rapid innate and slower adaptive response, is widely viewed as proinflammatory and/or cytolytic. However, increasing evidence that different cytokines drive widely different effector functions in alphabeta T cells provoked us to apply cDNA microarrays to explore the potential pleiotropy of HMB-PP-activated Vgamma9/Vdelta2 T cells. The data and accompanying validations show that the related cytokines, IL-2, IL-4, or IL-21, each drive proliferation and comparable CD69 up-regulatio","dates":{"release":"2007-01-01T00:00:00Z","publication":"2007 Apr","modification":"2026-04-07T23:57:09.043Z","creation":"2026-04-07T19:20:54.081Z"},"accession":"S-EPMC3915340","cross_references":{"pubmed":["17371987"],"doi":["10.4049/jimmunol.178.7.4304"]}}