biostudies-literatureVermijlen DWellcome Trust4304-14https://www.ebi.ac.uk/biostudies/studies/S-EPMC3915340biostudies-literatureUnknown178(7)Human Vgamma9/Vdelta2 T cells comprise a small population of peripheral blood T cells that in many infectious diseases respond to the microbial metabolite, (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate (HMB-PP), expanding to up to 50% of CD3(+) cells. This "transitional response," occurring temporally between the rapid innate and slower adaptive response, is widely viewed as proinflammatory and/or cytolytic. However, increasing evidence that different cytokines drive widely different effector functions in alphabeta T cells provoked us to apply cDNA microarrays to explore the potential pleiotropy of HMB-PP-activated Vgamma9/Vdelta2 T cells. The data and accompanying validations show that the related cytokines, IL-2, IL-4, or IL-21, each drive proliferation and comparable CD69 up-regulatioJournal of immunology (Baltimore, Md. : 1950)Distinct cytokine-driven responses of activated blood gammadelta T cells: insights into unconventional T cell pleiotropy.PMC3915340071534Hayday ACLangford CEberl MEllis PJomaa HKlein AVermijlen DWillimann KEngel RfalseDistinct cytokine-driven responses of activated blood gammadelta T cells: insights into unconventional T cell pleiotropy.Human Vgamma9/Vdelta2 T cells comprise a small population of peripheral blood T cells that in many infectious diseases respond to the microbial metabolite, (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate (HMB-PP), expanding to up to 50% of CD3(+) cells. This "transitional response," occurring temporally between the rapid innate and slower adaptive response, is widely viewed as proinflammatory and/or cytolytic. However, increasing evidence that different cytokines drive widely different effector functions in alphabeta T cells provoked us to apply cDNA microarrays to explore the potential pleiotropy of HMB-PP-activated Vgamma9/Vdelta2 T cells. The data and accompanying validations show that the related cytokines, IL-2, IL-4, or IL-21, each drive proliferation and comparable CD69 up-regulatio2007-01-01T00:00:00Z2007 Apr2026-04-07T23:57:09.043Z2026-04-07T19:20:54.081ZS-EPMC39153401737198710.4049/jimmunol.178.7.4304