{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["22(2)"],"submitter":["Weng TY"],"pubmed_abstract":["Induction of thrombospondin 1 (TSP-1) is generally assumed to suppress tumor growth through inhibiting angiogenesis; however, it is less clear how TSP-1 in dendritic cells (DCs) influences tumor progression. We investigated tumor growth and immune mechanism by downregulation of TSP-1 in dendritic cells. Administration of TSP-1 small hairpin RNA (shRNA) through the skin produced anticancer therapeutic effects. Tumor-infiltrating CD4(+) and CD8(+) T cells were increased after the administration of TSP-1 shRNA. The expression of interleukin-12 and interferon-γ in the lymph nodes was enhanced by injection of TSP-1 shRNA. Lymphocytes from the mice injected with TSP-1 shRNA selectively killed the tumor cells, and the cytotoxicity of lymphocytes was abolished by depletion of CD8(+) T cells. Injec"],"journal":["Molecular therapy : the journal of the American Society of Gene Therapy"],"pagination":["292-302"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3918914"],"repository":["biostudies-literature"],"pubmed_title":["A novel cancer therapeutic using thrombospondin 1 in dendritic cells."],"pmcid":["PMC3918914"],"pubmed_authors":["Chang JY","Huang SS","Wang CY","Lin CM","Lai MD","Yen MC","Lin CC","Chen WC","Weng TY","Chen YL"],"additional_accession":[]},"is_claimable":false,"name":"A novel cancer therapeutic using thrombospondin 1 in dendritic cells.","description":"Induction of thrombospondin 1 (TSP-1) is generally assumed to suppress tumor growth through inhibiting angiogenesis; however, it is less clear how TSP-1 in dendritic cells (DCs) influences tumor progression. We investigated tumor growth and immune mechanism by downregulation of TSP-1 in dendritic cells. Administration of TSP-1 small hairpin RNA (shRNA) through the skin produced anticancer therapeutic effects. Tumor-infiltrating CD4(+) and CD8(+) T cells were increased after the administration of TSP-1 shRNA. The expression of interleukin-12 and interferon-γ in the lymph nodes was enhanced by injection of TSP-1 shRNA. Lymphocytes from the mice injected with TSP-1 shRNA selectively killed the tumor cells, and the cytotoxicity of lymphocytes was abolished by depletion of CD8(+) T cells. Injec","dates":{"release":"2014-01-01T00:00:00Z","publication":"2014 Feb","modification":"2026-04-29T22:36:41.379Z","creation":"2019-03-27T01:21:30Z"},"accession":"S-EPMC3918914","cross_references":{"pubmed":["24127010"],"doi":["10.1038/mt.2013.236"]}}