{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Veldhuis JD"],"funding":["NCATS NIH HHS","NIA NIH HHS","NIDDK NIH HHS"],"pagination":["205-15"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3920108"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["9(4)"],"pubmed_abstract":["The pituitary gland has a role in puberty, reproduction, stress-adaptive responses, sodium and water balance, uterine contractions, lactation, thyroid function, growth, body composition and skin pigmentation. Ageing is marked by initially subtle erosion of physiological signalling mechanisms, resulting in lower incremental secretory-burst amplitude, more disorderly patterns of pituitary hormone release and blunted 24 h rhythmic secretion. Almost all pituitary hormones are altered by ageing in humans, often in a manner dependent on sex, body composition, stress, comorbidity, intercurrent illness, medication use, physical frailty, caloric intake, immune status, level of exercise, and neurocognitive decline. The aim of this article is to critically discuss the mechanisms mediating clinical facets of changes in the hypothalamic-pituitary axis during ageing, and the extent to which confounding factors operate to obscure ageing-related effects."],"journal":["Nature reviews. Endocrinology"],"pubmed_title":["Changes in pituitary function with ageing and implications for patient care."],"pmcid":["PMC3920108"],"funding_grant_id":["R01 DK073148","R37 AG019695","R01 AG031763","AG029362","R01 AG029362","UL1 TR000135","P30 DK050456","AG031763","DK073148","DK050456","R01 AG019695","AG019695"],"pubmed_authors":["Veldhuis JD"],"additional_accession":[]},"is_claimable":false,"name":"Changes in pituitary function with ageing and implications for patient care.","description":"The pituitary gland has a role in puberty, reproduction, stress-adaptive responses, sodium and water balance, uterine contractions, lactation, thyroid function, growth, body composition and skin pigmentation. Ageing is marked by initially subtle erosion of physiological signalling mechanisms, resulting in lower incremental secretory-burst amplitude, more disorderly patterns of pituitary hormone release and blunted 24 h rhythmic secretion. Almost all pituitary hormones are altered by ageing in humans, often in a manner dependent on sex, body composition, stress, comorbidity, intercurrent illness, medication use, physical frailty, caloric intake, immune status, level of exercise, and neurocognitive decline. The aim of this article is to critically discuss the mechanisms mediating clinical facets of changes in the hypothalamic-pituitary axis during ageing, and the extent to which confounding factors operate to obscure ageing-related effects.","dates":{"release":"2013-01-01T00:00:00Z","publication":"2013 Apr","modification":"2025-04-05T11:49:47.146Z","creation":"2019-03-27T01:21:34Z"},"accession":"S-EPMC3920108","cross_references":{"pubmed":["23438832"],"doi":["10.1038/nrendo.2013.38"]}}