{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Martindale JJ"],"funding":["NIA NIH HHS","NHLBI NIH HHS"],"pagination":["26-37"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3920738"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["67"],"pubmed_abstract":["Myocardial ischemia/reperfusion (I/R) injury is a major clinical problem leading to cardiac dysfunction and myocyte death. It is widely held that I/R causes damage to membrane phospholipids, and is a significant mechanism of cardiac I/R injury. Molecular dissection of sarcolemmal damage in I/R, however, has been difficult to address experimentally. We studied here cardiac I/R injury under conditions targeting gain- or loss-of sarcolemma integrity. To implement gain-in-sarcolemma integrity during I/R, synthetic copolymer-based sarcolemmal stabilizers (CSS), including Poloxamer 188 (P188), were used as a tool to directly stabilize the sarcolemma. Consistent with the hypothesis of sarcolemmal stabilization, cellular markers of necrosis and apoptosis evident in untreated myocytes were fully bl"],"journal":["Journal of molecular and cellular cardiology"],"pubmed_title":["Uncoupling of increased cellular oxidative stress and myocardial ischemia reperfusion injury by directed sarcolemma stabilization."],"pmcid":["PMC3920738"],"funding_grant_id":["R01 HL059301","R01 AG034107","R01 HL122323"],"pubmed_authors":["Martindale JJ","Metzger JM"],"additional_accession":[]},"is_claimable":false,"name":"Uncoupling of increased cellular oxidative stress and myocardial ischemia reperfusion injury by directed sarcolemma stabilization.","description":"Myocardial ischemia/reperfusion (I/R) injury is a major clinical problem leading to cardiac dysfunction and myocyte death. It is widely held that I/R causes damage to membrane phospholipids, and is a significant mechanism of cardiac I/R injury. Molecular dissection of sarcolemmal damage in I/R, however, has been difficult to address experimentally. We studied here cardiac I/R injury under conditions targeting gain- or loss-of sarcolemma integrity. To implement gain-in-sarcolemma integrity during I/R, synthetic copolymer-based sarcolemmal stabilizers (CSS), including Poloxamer 188 (P188), were used as a tool to directly stabilize the sarcolemma. Consistent with the hypothesis of sarcolemmal stabilization, cellular markers of necrosis and apoptosis evident in untreated myocytes were fully bl","dates":{"release":"2014-01-01T00:00:00Z","publication":"2014 Feb","modification":"2025-04-05T11:49:47.768Z","creation":"2019-03-27T01:21:37Z"},"accession":"S-EPMC3920738","cross_references":{"pubmed":["24362314"],"doi":["10.1016/j.yjmcc.2013.12.008"]}}