biostudies-literatureYang MSNINDS NIH HHS132-7https://www.ebi.ac.uk/biostudies/studies/S-EPMC3921115biostudies-literatureUnknown15(1)<h4>Objective and background</h4>Individuals with restless legs syndrome (RLS) (Willis-Ekbom disease [WED]) usually have periodic leg movements (PLMs). The suggested immobilization test (SIT) measures sensory and motor features of WED during wakefulness. Surface electromyogram (EMG) recordings of the anterior tibialis (AT) are used as the standard for counting PLMs. However, due to several limitations, leg activity meters such as the PAM-RL were advanced as a potential substitute. In our study, we assessed the validity of the measurements of PLM during wakefulness (PLMW) in the SIT for PAM-RL using both default and custom detection threshold parameters compared to AT EMG.<h4>Methods</h4>Data were obtained from 39 participants who were diagnosed with primary WED and who were on stable medicSleep medicineValid measures of periodic leg movements (PLMs) during a suggested immobilization test using the PAM-RL leg activity monitors require adjusting detection parameters for noise and signal in each recording.PMC3921115R01 NS075184Montplaisir JEarley CJDesautels AYang MSAllen RPWinkelman JWCramer Bornemann MAfalseValid measures of periodic leg movements (PLMs) during a suggested immobilization test using the PAM-RL leg activity monitors require adjusting detection parameters for noise and signal in each recording.<h4>Objective and background</h4>Individuals with restless legs syndrome (RLS) (Willis-Ekbom disease [WED]) usually have periodic leg movements (PLMs). The suggested immobilization test (SIT) measures sensory and motor features of WED during wakefulness. Surface electromyogram (EMG) recordings of the anterior tibialis (AT) are used as the standard for counting PLMs. However, due to several limitations, leg activity meters such as the PAM-RL were advanced as a potential substitute. In our study, we assessed the validity of the measurements of PLM during wakefulness (PLMW) in the SIT for PAM-RL using both default and custom detection threshold parameters compared to AT EMG.<h4>Methods</h4>Data were obtained from 39 participants who were diagnosed with primary WED and who were on stable medic2014-01-01T00:00:00Z2014 Jan2025-04-05T11:49:40.291Z2019-03-27T01:21:38ZS-EPMC39211152433204610.1016/j.sleep.2013.08.788