{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zheng T"],"funding":["Biotechnology and Biological Sciences Research Council"],"pagination":["2182-7"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3926089"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["111(6)"],"pubmed_abstract":["The Arabidopsis cyclin-dependent kinase G (CDKG) gene defines a clade of cyclin-dependent protein kinases related to CDK10 and CDK11, as well as to the enigmatic Ph1-related kinases that are implicated in controlling homeologous chromosome pairing in wheat. Here we demonstrate that the CDKG1/CYCLINL complex is essential for synapsis and recombination during male meiosis. A transfer-DNA insertional mutation in the cdkg1 gene leads to a temperature-sensitive failure of meiosis in late Zygotene/Pachytene that is associated with defective formation of the synaptonemal complex, reduced bivalent formation and crossing over, and aneuploid gametes. An aphenotypic insertion in the cyclin L gene, a cognate cyclin for CDKG, strongly enhances the phenotype of cdkg1-1 mutants, indicating that this cdk-"],"journal":["Proceedings of the National Academy of Sciences of the United States of America"],"pubmed_title":["CDKG1 protein kinase is essential for synapsis and male meiosis at high ambient temperature in Arabidopsis thaliana."],"pmcid":["PMC3926089"],"funding_grant_id":["BBS/E/W/10962A01B","BB/F018754/1","BB/J007633/1","BBS/E/J/0000A216","BB/J004405/1"],"pubmed_authors":["Phillips DW","Jenkins G","Doonan JH","Nibau C","Zheng T","Armstrong SJ"],"additional_accession":[]},"is_claimable":false,"name":"CDKG1 protein kinase is essential for synapsis and male meiosis at high ambient temperature in Arabidopsis thaliana.","description":"The Arabidopsis cyclin-dependent kinase G (CDKG) gene defines a clade of cyclin-dependent protein kinases related to CDK10 and CDK11, as well as to the enigmatic Ph1-related kinases that are implicated in controlling homeologous chromosome pairing in wheat. Here we demonstrate that the CDKG1/CYCLINL complex is essential for synapsis and recombination during male meiosis. A transfer-DNA insertional mutation in the cdkg1 gene leads to a temperature-sensitive failure of meiosis in late Zygotene/Pachytene that is associated with defective formation of the synaptonemal complex, reduced bivalent formation and crossing over, and aneuploid gametes. An aphenotypic insertion in the cyclin L gene, a cognate cyclin for CDKG, strongly enhances the phenotype of cdkg1-1 mutants, indicating that this cdk-","dates":{"release":"2014-01-01T00:00:00Z","publication":"2014 Feb","modification":"2025-04-04T21:13:38.353Z","creation":"2019-03-27T01:21:53Z"},"accession":"S-EPMC3926089","cross_references":{"pubmed":["24469829"],"doi":["10.1073/pnas.1318460111"]}}