{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["18(2)"],"submitter":["Zhou J"],"pubmed_abstract":["Stem cell transplantation represents a promising strategy for the repair of spinal cord injury (SCI). However, the low survival rate of the grafted cells is a major obstacle hindering clinical success because of ongoing secondary injury processes, which includes excitotoxicity, inflammation and oxidative stress. Previous studies have shown that 17b-estradiol (E2) protects several cell types against cytotoxicity. Thus, we examined the effects of E2 on the viability of human eyelid adipose-derived stem cells (hEASCs) in vitro with hydrogen peroxide (H₂O₂)-induced cell model and in vivo within a rat SCI model. Our results showed that E2 protected hEASCs against H₂O₂-induced cell death in vitro, and enhanced the survival of grafted hEASCs in vivo by reducing apoptosis. Additionally, E2 also en"],"journal":["Journal of cellular and molecular medicine"],"pagination":["326-43"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3930419"],"repository":["biostudies-literature"],"pubmed_title":["17β-estradiol protects human eyelid-derived adipose stem cells against cytotoxicity and increases transplanted cell survival in spinal cord injury."],"pmcid":["PMC3930419"],"pubmed_authors":["Ren H","Liu H","Zheng Z","Ling S","Jiang F","Ouyang H","Hu X","Ji J","Heng BC","Lu P","Zhou J"],"additional_accession":[]},"is_claimable":false,"name":"17β-estradiol protects human eyelid-derived adipose stem cells against cytotoxicity and increases transplanted cell survival in spinal cord injury.","description":"Stem cell transplantation represents a promising strategy for the repair of spinal cord injury (SCI). However, the low survival rate of the grafted cells is a major obstacle hindering clinical success because of ongoing secondary injury processes, which includes excitotoxicity, inflammation and oxidative stress. Previous studies have shown that 17b-estradiol (E2) protects several cell types against cytotoxicity. Thus, we examined the effects of E2 on the viability of human eyelid adipose-derived stem cells (hEASCs) in vitro with hydrogen peroxide (H₂O₂)-induced cell model and in vivo within a rat SCI model. Our results showed that E2 protected hEASCs against H₂O₂-induced cell death in vitro, and enhanced the survival of grafted hEASCs in vivo by reducing apoptosis. Additionally, E2 also en","dates":{"release":"2014-01-01T00:00:00Z","publication":"2014 Feb","modification":"2026-04-07T17:09:03.487Z","creation":"2026-04-07T15:48:42.03Z"},"accession":"S-EPMC3930419","cross_references":{"pubmed":["24373095"],"doi":["10.1111/jcmm.12191"]}}