biostudies-literatureGerns Storey HLNICHD NIH HHSNCRR NIH HHSNIAID NIH HHS37-44https://www.ebi.ac.uk/biostudies/studies/S-EPMC3931433biostudies-literatureUnknown30(1)The role of HIV-1-specific antibody responses in HIV disease progression is complex and would benefit from analysis techniques that examine clusterings of responses. Protein microarray platforms facilitate the simultaneous evaluation of numerous protein-specific antibody responses, though excessive data are cumbersome in analyses. Principal components analysis (PCA) reduces data dimensionality by generating fewer composite variables that maximally account for variance in a dataset. To identify clusters of antibody responses involved in disease control, we investigated the association of HIV-1-specific antibody responses by protein microarray, and assessed their association with disease progression using PCA in a nested cohort design. Associations observed among collections of antibody respAIDS research and human retrovirusesUse of principal components analysis and protein microarray to explore the association of HIV-1-specific IgG responses with disease progression.PMC3931433K24 HD0543145U01AI078213-05TL1 RR025016Walson JLCamerini DSinga BNaulikha JFelgner PLHorton HDiaz-Ochoa VEJohn-Stewart GGerns Storey HLPrindle VCRichardson BAfalseUse of principal components analysis and protein microarray to explore the association of HIV-1-specific IgG responses with disease progression.The role of HIV-1-specific antibody responses in HIV disease progression is complex and would benefit from analysis techniques that examine clusterings of responses. Protein microarray platforms facilitate the simultaneous evaluation of numerous protein-specific antibody responses, though excessive data are cumbersome in analyses. Principal components analysis (PCA) reduces data dimensionality by generating fewer composite variables that maximally account for variance in a dataset. To identify clusters of antibody responses involved in disease control, we investigated the association of HIV-1-specific antibody responses by protein microarray, and assessed their association with disease progression using PCA in a nested cohort design. Associations observed among collections of antibody resp2014-01-01T00:00:00Z2014 Jan2026-04-07T14:00:19.327Z2019-03-27T01:22:13ZS-EPMC39314332413422110.1089/AID.2013.008810.1089/aid.2013.0088