{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Grossman GH"],"funding":["NEI NIH HHS"],"pagination":["129-39"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3936680"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["30(4)"],"pubmed_abstract":["Dynamin proteins are involved in vesicle generation, providing mechanical force to excise newly formed vesicles from membranes of cellular compartments. In the brain, dynamin-1, dynamin-2, and dynamin-3 have been well studied; however, their function in the retina remains elusive. A retina-specific splice variant of dynamin-1 interacts with the photoreceptor-specific protein Tubby-like protein 1 (Tulp1), which when mutated causes an early onset form of autosomal recessive retinitis pigmentosa. Here, we investigated the role of the dynamins in the retina, using immunohistochemistry to localize dynamin-1, dynamin-2, and dynamin-3 and immunoprecipitation followed by mass spectrometry to explore dynamin-1 interacting proteins in mouse retina. Dynamin-2 is primarily confined to the inner segmen"],"journal":["Visual neuroscience"],"pubmed_title":["Protein partners of dynamin-1 in the retina."],"pmcid":["PMC3936680"],"funding_grant_id":["R01 EY016072","NIH EY15638"],"pubmed_authors":["Grossman GH","Hagstrom SA","Ebke LA","Crabb JW","Beight CD","Jang GF"],"additional_accession":[]},"is_claimable":false,"name":"Protein partners of dynamin-1 in the retina.","description":"Dynamin proteins are involved in vesicle generation, providing mechanical force to excise newly formed vesicles from membranes of cellular compartments. In the brain, dynamin-1, dynamin-2, and dynamin-3 have been well studied; however, their function in the retina remains elusive. A retina-specific splice variant of dynamin-1 interacts with the photoreceptor-specific protein Tubby-like protein 1 (Tulp1), which when mutated causes an early onset form of autosomal recessive retinitis pigmentosa. Here, we investigated the role of the dynamins in the retina, using immunohistochemistry to localize dynamin-1, dynamin-2, and dynamin-3 and immunoprecipitation followed by mass spectrometry to explore dynamin-1 interacting proteins in mouse retina. Dynamin-2 is primarily confined to the inner segmen","dates":{"release":"2013-01-01T00:00:00Z","publication":"2013 Jul","modification":"2026-05-01T02:13:47.917Z","creation":"2026-04-07T16:33:55.603Z"},"accession":"S-EPMC3936680","cross_references":{"pubmed":["23746204"],"doi":["10.1017/s0952523813000138","10.1017/S0952523813000138"]}}