biostudies-literatureGrossman GHNEI NIH HHS129-39https://www.ebi.ac.uk/biostudies/studies/S-EPMC3936680biostudies-literatureUnknown30(4)Dynamin proteins are involved in vesicle generation, providing mechanical force to excise newly formed vesicles from membranes of cellular compartments. In the brain, dynamin-1, dynamin-2, and dynamin-3 have been well studied; however, their function in the retina remains elusive. A retina-specific splice variant of dynamin-1 interacts with the photoreceptor-specific protein Tubby-like protein 1 (Tulp1), which when mutated causes an early onset form of autosomal recessive retinitis pigmentosa. Here, we investigated the role of the dynamins in the retina, using immunohistochemistry to localize dynamin-1, dynamin-2, and dynamin-3 and immunoprecipitation followed by mass spectrometry to explore dynamin-1 interacting proteins in mouse retina. Dynamin-2 is primarily confined to the inner segmenVisual neuroscienceProtein partners of dynamin-1 in the retina.PMC3936680R01 EY016072NIH EY15638Grossman GHHagstrom SAEbke LACrabb JWBeight CDJang GFfalseProtein partners of dynamin-1 in the retina.Dynamin proteins are involved in vesicle generation, providing mechanical force to excise newly formed vesicles from membranes of cellular compartments. In the brain, dynamin-1, dynamin-2, and dynamin-3 have been well studied; however, their function in the retina remains elusive. A retina-specific splice variant of dynamin-1 interacts with the photoreceptor-specific protein Tubby-like protein 1 (Tulp1), which when mutated causes an early onset form of autosomal recessive retinitis pigmentosa. Here, we investigated the role of the dynamins in the retina, using immunohistochemistry to localize dynamin-1, dynamin-2, and dynamin-3 and immunoprecipitation followed by mass spectrometry to explore dynamin-1 interacting proteins in mouse retina. Dynamin-2 is primarily confined to the inner segmen2013-01-01T00:00:00Z2013 Jul2026-05-01T02:13:47.917Z2026-04-07T16:33:55.603ZS-EPMC39366802374620410.1017/s095252381300013810.1017/S0952523813000138