{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Li M"],"funding":["NICHD NIH HHS","NIA NIH HHS","Medical Research Council","NINDS NIH HHS","Lundbeck Foundation"],"pagination":["452-61"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3937299"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["19(4)"],"pubmed_abstract":["Bipolar disorder (BD) is a polygenic disorder that shares substantial genetic risk factors with major depressive disorder (MDD). Genetic analyses have reported numerous BD susceptibility genes, while some variants, such as single-nucleotide polymorphisms (SNPs) in CACNA1C have been successfully replicated, many others have not and subsequently their effects on the intermediate phenotypes cannot be verified. Here, we studied the MDD-related gene CREB1 in a set of independent BD sample groups of European ancestry (a total of 64,888 subjects) and identified multiple SNPs significantly associated with BD (the most significant being SNP rs6785[A], P=6.32 × 10(-5), odds ratio (OR)=1.090). Risk SNPs were then subjected to further analyses in healthy Europeans for intermediate phenotypes of BD, in"],"journal":["Molecular psychiatry"],"pubmed_title":["Allelic differences between Europeans and Chinese for CREB1 SNPs and their implications in gene expression regulation, hippocampal structure and function, and bipolar disorder susceptibility."],"pmcid":["PMC3937299"],"funding_grant_id":["U24 AG021886","U01 AG049505","G9817803B","R01 NS017950","R155-2014-1724","P30 AG010129","R01 HD050735","R01 AG008122"],"pubmed_authors":["Shi L","Lin Q","Su B","Martin NG","Cichon S","Rietschel M","Nothen MM","Gill M","Hibar DP","Medland SE","Jamain S","Ikram MA","Sullivan PF","Leboyer M","Walter H","CHARGE Consortium","Donohoe G","Corvin A","Debette S","Arias Vasquez A","Li M","Hargreaves A","Stein JL","Muller-Myhsok B","Luo XJ","Thompson PM","Fornage M","Hultman C","Morris DW","ENIGMA Consortium","Henry C","Franke B","Toga AW","Heinz A","Alzheimer’s Disease Neuroimaging Initiative","Czamara D","Mattheisen M","Bergen SE","MooDS Bipolar Consortium","Meyer-Lindenberg A","Lewis CM","Landen M","Wright MJ","Bellivier F","Swedish Bipolar Study Group","Seshadri S","Erk S","Etain B","Bis JC","Schulze TG","Gan L","Launer LJ","Shi H"],"additional_accession":[]},"is_claimable":false,"name":"Allelic differences between Europeans and Chinese for CREB1 SNPs and their implications in gene expression regulation, hippocampal structure and function, and bipolar disorder susceptibility.","description":"Bipolar disorder (BD) is a polygenic disorder that shares substantial genetic risk factors with major depressive disorder (MDD). Genetic analyses have reported numerous BD susceptibility genes, while some variants, such as single-nucleotide polymorphisms (SNPs) in CACNA1C have been successfully replicated, many others have not and subsequently their effects on the intermediate phenotypes cannot be verified. Here, we studied the MDD-related gene CREB1 in a set of independent BD sample groups of European ancestry (a total of 64,888 subjects) and identified multiple SNPs significantly associated with BD (the most significant being SNP rs6785[A], P=6.32 × 10(-5), odds ratio (OR)=1.090). Risk SNPs were then subjected to further analyses in healthy Europeans for intermediate phenotypes of BD, in","dates":{"release":"2014-01-01T00:00:00Z","publication":"2014 Apr","modification":"2026-05-04T09:06:27.033Z","creation":"2019-03-27T01:22:29Z"},"accession":"S-EPMC3937299","cross_references":{"pubmed":["23568192"],"doi":["10.1038/mp.2013.37"]}}