biostudies-literatureLi MNICHD NIH HHSNIA NIH HHSMedical Research CouncilNINDS NIH HHSLundbeck Foundation452-61https://www.ebi.ac.uk/biostudies/studies/S-EPMC3937299biostudies-literatureUnknown19(4)Bipolar disorder (BD) is a polygenic disorder that shares substantial genetic risk factors with major depressive disorder (MDD). Genetic analyses have reported numerous BD susceptibility genes, while some variants, such as single-nucleotide polymorphisms (SNPs) in CACNA1C have been successfully replicated, many others have not and subsequently their effects on the intermediate phenotypes cannot be verified. Here, we studied the MDD-related gene CREB1 in a set of independent BD sample groups of European ancestry (a total of 64,888 subjects) and identified multiple SNPs significantly associated with BD (the most significant being SNP rs6785[A], P=6.32 × 10(-5), odds ratio (OR)=1.090). Risk SNPs were then subjected to further analyses in healthy Europeans for intermediate phenotypes of BD, inMolecular psychiatryAllelic differences between Europeans and Chinese for CREB1 SNPs and their implications in gene expression regulation, hippocampal structure and function, and bipolar disorder susceptibility.PMC3937299U24 AG021886U01 AG049505G9817803BR01 NS017950R155-2014-1724P30 AG010129R01 HD050735R01 AG008122Shi LLin QSu BMartin NGCichon SRietschel MNothen MMGill MHibar DPMedland SEJamain SIkram MASullivan PFLeboyer MWalter HCHARGE ConsortiumDonohoe GCorvin ADebette SArias Vasquez ALi MHargreaves AStein JLMuller-Myhsok BLuo XJThompson PMFornage MHultman CMorris DWENIGMA ConsortiumHenry CFranke BToga AWHeinz AAlzheimer’s Disease Neuroimaging InitiativeCzamara DMattheisen MBergen SEMooDS Bipolar ConsortiumMeyer-Lindenberg ALewis CMLanden MWright MJBellivier FSwedish Bipolar Study GroupSeshadri SErk SEtain BBis JCSchulze TGGan LLauner LJShi HfalseAllelic differences between Europeans and Chinese for CREB1 SNPs and their implications in gene expression regulation, hippocampal structure and function, and bipolar disorder susceptibility.Bipolar disorder (BD) is a polygenic disorder that shares substantial genetic risk factors with major depressive disorder (MDD). Genetic analyses have reported numerous BD susceptibility genes, while some variants, such as single-nucleotide polymorphisms (SNPs) in CACNA1C have been successfully replicated, many others have not and subsequently their effects on the intermediate phenotypes cannot be verified. Here, we studied the MDD-related gene CREB1 in a set of independent BD sample groups of European ancestry (a total of 64,888 subjects) and identified multiple SNPs significantly associated with BD (the most significant being SNP rs6785[A], P=6.32 × 10(-5), odds ratio (OR)=1.090). Risk SNPs were then subjected to further analyses in healthy Europeans for intermediate phenotypes of BD, in2014-01-01T00:00:00Z2014 Apr2026-05-04T09:06:27.033Z2019-03-27T01:22:29ZS-EPMC39372992356819210.1038/mp.2013.37