{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["14(1)"],"submitter":["Dahl LD"],"pubmed_abstract":["Background
The oncogene PTI-1 was originally isolated from a prostate cancer cell line by its capability to transform rat fibroblasts. The PTI-1 mRNA has a very eccentric structure as the 5'UTR is similar to prokaryotic 23S rRNA, while the major open reading frame and the 3'UTR corresponds to a part of the mRNA encoding human translation elongation factor eEF1A1. Thus, the largest open reading frame encodes a truncated version of eEF1A1 lacking the first 67 amino acids, while having three unique N-terminal amino acids. Previously, the UTRs were shown to be a prerequisite for the transforming capacity of the PTI-1 transcript. In this study, we have investigated the possible role of the UTRs in regulating protein expression and localization.Methods
The protein expression prof"],"journal":["Cancer cell international"],"pagination":["17"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3941776"],"repository":["biostudies-literature"],"pubmed_title":["An eEF1A1 truncation encoded by PTI-1 exerts its oncogenic effect inside the nucleus."],"pmcid":["PMC3941776"],"pubmed_authors":["Nielsen KM","Fuchtbauer EM","Corydon TJ","Knudsen CR","Rankel L","Dahl LD"],"additional_accession":[]},"is_claimable":false,"name":"An eEF1A1 truncation encoded by PTI-1 exerts its oncogenic effect inside the nucleus.","description":"Background
The oncogene PTI-1 was originally isolated from a prostate cancer cell line by its capability to transform rat fibroblasts. The PTI-1 mRNA has a very eccentric structure as the 5'UTR is similar to prokaryotic 23S rRNA, while the major open reading frame and the 3'UTR corresponds to a part of the mRNA encoding human translation elongation factor eEF1A1. Thus, the largest open reading frame encodes a truncated version of eEF1A1 lacking the first 67 amino acids, while having three unique N-terminal amino acids. Previously, the UTRs were shown to be a prerequisite for the transforming capacity of the PTI-1 transcript. In this study, we have investigated the possible role of the UTRs in regulating protein expression and localization.Methods
The protein expression prof","dates":{"release":"2014-01-01T00:00:00Z","publication":"2014 Feb","modification":"2025-05-18T11:42:01.105Z","creation":"2025-05-18T11:42:01.105Z"},"accession":"S-EPMC3941776","cross_references":{"pubmed":["24571548"],"doi":["10.1186/1475-2867-14-17"]}}