biostudies-literatureWang XNIDDK NIH HHS677-85https://www.ebi.ac.uk/biostudies/studies/S-EPMC3943620biostudies-literatureUnknown85(3)The kidney atrophies in patients with advanced chronic kidney disease (CKD) but factors influencing kidney size in normal adults are less clear. To help define this, we measured kidney volumes on contrast-enhanced computed tomographic images from 1344 potential kidney donors (aged 18-75 years). Cortical volume per body surface area progressively declined in both genders with increased age. Statistically, this was primarily dependent on the age-related decline in glomerular filtration rate (GFR). Independent predictors of increased cortical volume per body surface area were male gender, increased GFR, increased 24-h urine albumin, current smoker, and decreased high-density lipid cholesterol. Medullary volume per body surface area increased with age in men, while it increased with age in womKidney internationalAge, kidney function, and risk factors associate differently with cortical and medullary volumes of the kidney.PMC3943620R01 DK090358Rule ADChakkera HALerman LOVrtiska TJWang XWalters LRAvula RTKremers WKfalseAge, kidney function, and risk factors associate differently with cortical and medullary volumes of the kidney.The kidney atrophies in patients with advanced chronic kidney disease (CKD) but factors influencing kidney size in normal adults are less clear. To help define this, we measured kidney volumes on contrast-enhanced computed tomographic images from 1344 potential kidney donors (aged 18-75 years). Cortical volume per body surface area progressively declined in both genders with increased age. Statistically, this was primarily dependent on the age-related decline in glomerular filtration rate (GFR). Independent predictors of increased cortical volume per body surface area were male gender, increased GFR, increased 24-h urine albumin, current smoker, and decreased high-density lipid cholesterol. Medullary volume per body surface area increased with age in men, while it increased with age in wom2014-01-01T00:00:00Z2014 Mar2025-04-04T14:14:17.45Z2019-03-27T01:22:44ZS-EPMC39436202406743710.1038/ki.2013.359