{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Peltekova VD"],"funding":["NCI NIH HHS","CIHR"],"pagination":["2330-41"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3949167"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["134(10)"],"pubmed_abstract":["A locus on human chromosome 11q23 tagged by marker rs3802842 was associated with colorectal cancer (CRC) in a genome-wide association study; this finding has been replicated in case-control studies worldwide. In order to identify biologic factors at this locus that are related to the etiopathology of CRC, we used microarray-based target selection methods, coupled to next-generation sequencing, to study 103 kb at the 11q23 locus. We genotyped 369 putative variants from 1,030 patients with CRC (cases) and 1,061 individuals without CRC (controls) from the Ontario Familial Colorectal Cancer Registry. Two previously uncharacterized genes, COLCA1 and COLCA2, were found to be co-regulated genes that are transcribed from opposite strands. Expression levels of COLCA1 and COLCA2 transcripts correlat"],"journal":["International journal of cancer"],"pubmed_title":["Identification of genes expressed by immune cells of the colon that are regulated by colorectal cancer-associated variants."],"pmcid":["PMC3949167"],"funding_grant_id":["UM1 CA167551","U24 CA074783","U01 CA074783","CA-95-011"],"pubmed_authors":["Lee S","Trinh QM","Gryfe R","Hodgson L","Kozak K","Zaidi SH","McPherson JD","Qazi AM","Bielecki R","Zandi S","Wang J","Wang M","Peltekova VD","Rogers M","Gallinger S","Dick JE","Zanke BW","Kwan JY","Rangrej J","Timms L","Chan-Seng-Yue M","Beck T","D'Souza DJ","Stein LD","De Borja R","Volar M","Ash C","Pollett A","Boutros PC","Hudson TJ","Lemire M","Chong T"],"additional_accession":[]},"is_claimable":false,"name":"Identification of genes expressed by immune cells of the colon that are regulated by colorectal cancer-associated variants.","description":"A locus on human chromosome 11q23 tagged by marker rs3802842 was associated with colorectal cancer (CRC) in a genome-wide association study; this finding has been replicated in case-control studies worldwide. In order to identify biologic factors at this locus that are related to the etiopathology of CRC, we used microarray-based target selection methods, coupled to next-generation sequencing, to study 103 kb at the 11q23 locus. We genotyped 369 putative variants from 1,030 patients with CRC (cases) and 1,061 individuals without CRC (controls) from the Ontario Familial Colorectal Cancer Registry. Two previously uncharacterized genes, COLCA1 and COLCA2, were found to be co-regulated genes that are transcribed from opposite strands. Expression levels of COLCA1 and COLCA2 transcripts correlat","dates":{"release":"2014-01-01T00:00:00Z","publication":"2014 May","modification":"2026-05-03T07:06:08.566Z","creation":"2025-07-28T03:04:04.111Z"},"accession":"S-EPMC3949167","cross_references":{"pubmed":["24154973"],"doi":["10.1002/ijc.28557"]}}