{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["9(3)"],"submitter":["Lago BV"],"pubmed_abstract":["Hepatitis B virus genotype E (HBV/E) is highly prevalent in Western Africa. In this work, 30 HBV/E isolates from HBsAg positive Angolans (staff and visitors of a private hospital in Luanda) were genetically characterized: 16 of them were completely sequenced and the pre-S/S sequences of the remaining 14 were determined. A high proportion (12/30, 40%) of subjects tested positive for both HBsAg and anti-HBs markers. Deduced amino acid sequences revealed the existence of specific substitutions and deletions in the B- and T-cell epitopes of the surface antigen (pre-S1- and pre-S2 regions) of the virus isolates derived from 8/12 individuals with concurrent HBsAg/anti-HBs. Phylogenetic analysis performed with 231 HBV/E full-length sequences, including 16 from this study, showed that all isolates"],"journal":["PloS one"],"pagination":["e92223"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3954871"],"repository":["biostudies-literature"],"pubmed_title":["Analysis of complete nucleotide sequences of Angolan hepatitis B virus isolates reveals the existence of a separate lineage within genotype E."],"pmcid":["PMC3954871"],"pubmed_authors":["Gomes SA","Niel C","Ribas FS","Mello FC","Lago BV","Soares CC","Valente F"],"additional_accession":[]},"is_claimable":false,"name":"Analysis of complete nucleotide sequences of Angolan hepatitis B virus isolates reveals the existence of a separate lineage within genotype E.","description":"Hepatitis B virus genotype E (HBV/E) is highly prevalent in Western Africa. In this work, 30 HBV/E isolates from HBsAg positive Angolans (staff and visitors of a private hospital in Luanda) were genetically characterized: 16 of them were completely sequenced and the pre-S/S sequences of the remaining 14 were determined. A high proportion (12/30, 40%) of subjects tested positive for both HBsAg and anti-HBs markers. Deduced amino acid sequences revealed the existence of specific substitutions and deletions in the B- and T-cell epitopes of the surface antigen (pre-S1- and pre-S2 regions) of the virus isolates derived from 8/12 individuals with concurrent HBsAg/anti-HBs. Phylogenetic analysis performed with 231 HBV/E full-length sequences, including 16 from this study, showed that all isolates","dates":{"release":"2014-01-01T00:00:00Z","publication":"2014","modification":"2026-04-12T23:22:03.102Z","creation":"2019-03-26T23:24:10Z"},"accession":"S-EPMC3954871","cross_references":{"pubmed":["24632784"],"doi":["10.1371/journal.pone.0092223"]}}