{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Shaaban KA"],"funding":["NCATS NIH HHS","NCRR NIH HHS","NHLBI NIH HHS","NIGMS NIH HHS"],"pagination":["337-9"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3955409"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["28(5)"],"pubmed_abstract":["We report the production, isolation and structure elucidation of the sesquiterpene isopterocarpolone from an Appalachian isolate Streptomyces species RM-14-6. While isopterocarpolone was previously put forth as a putative plant metabolite, this study highlights the first native bacterial production of isopterocarpolone and the first full characterisation of isopterocarpolone using 1D and 2D NMR spectroscopy and HR-ESI mass spectrometry. Considering the biosynthesis of closely related metabolites (geosmin or 5-epiaristolochene), the structure of isopterocarpolone also suggests the potential participation of one or more unique enzymatic transformations. In this context, this work also sets the stage for the elucidation of potentially novel bacterial biosynthetic machinery."],"journal":["Natural product research"],"pubmed_title":["The native production of the sesquiterpene isopterocarpolone by Streptomyces sp. RM-14-6."],"pmcid":["PMC3955409"],"funding_grant_id":["P20 GM103527","S10 RR024598","UL1TR000117","P01 HL080166","UL1 TR000117","S10 RR026884"],"pubmed_authors":["Hower JC","Shaaban KA","Elshahawi SI","Kharel MK","Thorson JS","Sunkara M","Copley GC","Wang X","Singh S","Ponomareva LV","Morris AJ"],"additional_accession":[]},"is_claimable":false,"name":"The native production of the sesquiterpene isopterocarpolone by Streptomyces sp. RM-14-6.","description":"We report the production, isolation and structure elucidation of the sesquiterpene isopterocarpolone from an Appalachian isolate Streptomyces species RM-14-6. While isopterocarpolone was previously put forth as a putative plant metabolite, this study highlights the first native bacterial production of isopterocarpolone and the first full characterisation of isopterocarpolone using 1D and 2D NMR spectroscopy and HR-ESI mass spectrometry. Considering the biosynthesis of closely related metabolites (geosmin or 5-epiaristolochene), the structure of isopterocarpolone also suggests the potential participation of one or more unique enzymatic transformations. In this context, this work also sets the stage for the elucidation of potentially novel bacterial biosynthetic machinery.","dates":{"release":"2014-01-01T00:00:00Z","publication":"2014","modification":"2020-09-18T07:02:32Z","creation":"2019-03-27T01:23:29Z"},"accession":"S-EPMC3955409","cross_references":{"pubmed":["24237421"],"doi":["10.1080/14786419.2013.855932"]}}