{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Cairns LS"],"funding":["Wellcome Trust","Biotechnology and Biological Sciences Research Council"],"pagination":["6-21"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3963450"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["90(1)"],"pubmed_abstract":["In the natural environment bacteria predominantly live adhered to a surface as part of a biofilm. While many of the components needed for biofilm assembly are known, the mechanism by which microbes sense and respond to contact with a surface is poorly understood. Bacillus subtilis is a Gram-positive model for biofilm formation. The DegS-DegU two-component system controls several multicellular behaviours in B. subtilis, including biofilm formation. Here we identify the B. subtilis flagellum as a mechanosensor that activates the DegS-DegU regulatory pathway. Inhibition of flagellar rotation by deletion or mutation of the flagellar stator gene, motB, results in an increase in both degU transcription and DegU∼P driven processes, namely exoprotease production and poly-γ-dl-glutamic acid biosynt"],"journal":["Molecular microbiology"],"pubmed_title":["A mechanical signal transmitted by the flagellum controls signalling in Bacillus subtilis."],"pmcid":["PMC3963450"],"funding_grant_id":["BB/H002340/1","093714","097818/Z/11/A","BB/I006915/1","097945/B/11/Z","BB/D526161/1","093714/Z/10/Z"],"pubmed_authors":["Stanley-Wall NR","Marlow VL","Bissett E","Ostrowski A","Cairns LS"],"additional_accession":[]},"is_claimable":false,"name":"A mechanical signal transmitted by the flagellum controls signalling in Bacillus subtilis.","description":"In the natural environment bacteria predominantly live adhered to a surface as part of a biofilm. While many of the components needed for biofilm assembly are known, the mechanism by which microbes sense and respond to contact with a surface is poorly understood. Bacillus subtilis is a Gram-positive model for biofilm formation. The DegS-DegU two-component system controls several multicellular behaviours in B. subtilis, including biofilm formation. Here we identify the B. subtilis flagellum as a mechanosensor that activates the DegS-DegU regulatory pathway. Inhibition of flagellar rotation by deletion or mutation of the flagellar stator gene, motB, results in an increase in both degU transcription and DegU∼P driven processes, namely exoprotease production and poly-γ-dl-glutamic acid biosynt","dates":{"release":"2013-01-01T00:00:00Z","publication":"2013 Oct","modification":"2025-04-04T19:09:06.589Z","creation":"2019-03-27T01:23:51Z"},"accession":"S-EPMC3963450","cross_references":{"pubmed":["23888912"],"doi":["10.1111/mmi.12342"]}}