{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Chang TY"],"funding":["National Science Council"],"pagination":["156356"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3966419"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["2014"],"pubmed_abstract":["<h4>Background</h4>The most common gene-based cancer therapies involve the suppression of oncogenic molecules and enhancement of the expression of tumor-suppressor genes. Studies in noncancer disease animal models have shown that minicircle (MC) DNA vectors are easy to deliver and that the proteins from said MC-carrying DNA vectors are expressed over a long period of time. However, delivery of therapeutic genes via a liposome-mediated, MC DNA complex has never been tested in vascular-rich hepatocellular carcinoma (HCC). Liposome-mediated DNA delivery exhibits high in vivo transfection efficiency and minimal systemic immune response, thereby allowing for repetitive interventions. In this study, we evaluated the efficacy of delivering an MC-liposome vector containing a 3.2 kb androgen recept"],"journal":["BioMed research international"],"pubmed_title":["Durable expression of minicircle DNA-liposome-delivered androgen receptor cDNA in mice with hepatocellular carcinoma."],"pmcid":["PMC3966419"],"funding_grant_id":["NSC101-2314-B-039-027-MY3"],"pubmed_authors":["Chuang WM","Chung CY","Jeng LB","Ma WL","Chang TY","Li LY"],"additional_accession":[]},"is_claimable":false,"name":"Durable expression of minicircle DNA-liposome-delivered androgen receptor cDNA in mice with hepatocellular carcinoma.","description":"<h4>Background</h4>The most common gene-based cancer therapies involve the suppression of oncogenic molecules and enhancement of the expression of tumor-suppressor genes. Studies in noncancer disease animal models have shown that minicircle (MC) DNA vectors are easy to deliver and that the proteins from said MC-carrying DNA vectors are expressed over a long period of time. However, delivery of therapeutic genes via a liposome-mediated, MC DNA complex has never been tested in vascular-rich hepatocellular carcinoma (HCC). Liposome-mediated DNA delivery exhibits high in vivo transfection efficiency and minimal systemic immune response, thereby allowing for repetitive interventions. In this study, we evaluated the efficacy of delivering an MC-liposome vector containing a 3.2 kb androgen recept","dates":{"release":"2014-01-01T00:00:00Z","publication":"2014","modification":"2025-04-04T08:41:24.921Z","creation":"2019-03-27T01:23:59Z"},"accession":"S-EPMC3966419","cross_references":{"pubmed":["24734226"],"doi":["10.1155/2014/156356"]}}