biostudies-literatureEscudero DJUS National Institutes of Health (NIH)NICHD NIH HHSNIAID NIH HHSNIMH NIH HHSBrown University Richard B18899https://www.ebi.ac.uk/biostudies/studies/S-EPMC3969508biostudies-literatureUnknown17<h4>Introduction</h4>Studies examining the use of pre-exposure prophylaxis (PrEP) to prevent HIV transmission among people who inject drugs (PWIDs) have not been adequately summarized. Recently, the Bangkok Tenofovir Study has shown that PrEP may be effective at reducing new HIV infections among this high-risk group. This randomized controlled trial was the first study to specifically examine the efficacy of PrEP among PWIDs. In this review, we present the current state of evidence regarding the use of PrEP to prevent HIV infection in PWID populations, and set an agenda for future research to inform the most effective implementation of PrEP in the context of existing evidence-based HIV prevention strategies.<h4>Discussion</h4>Despite positive trial results confirming that PrEP may prevent Journal of the International AIDS SocietyHIV pre-exposure prophylaxis for people who inject drugs: a review of current results and an agenda for future research.PMC3969508P30 AI042853R01-MH083539R24 HD041020R01 MH106600R01 MH083539Howe CJMarshall BDEscudero DJLurie MNKerr TfalseHIV pre-exposure prophylaxis for people who inject drugs: a review of current results and an agenda for future research.<h4>Introduction</h4>Studies examining the use of pre-exposure prophylaxis (PrEP) to prevent HIV transmission among people who inject drugs (PWIDs) have not been adequately summarized. Recently, the Bangkok Tenofovir Study has shown that PrEP may be effective at reducing new HIV infections among this high-risk group. This randomized controlled trial was the first study to specifically examine the efficacy of PrEP among PWIDs. In this review, we present the current state of evidence regarding the use of PrEP to prevent HIV infection in PWID populations, and set an agenda for future research to inform the most effective implementation of PrEP in the context of existing evidence-based HIV prevention strategies.<h4>Discussion</h4>Despite positive trial results confirming that PrEP may prevent 2014-01-01T00:00:00Z20142025-04-22T01:03:08.467Z2019-03-27T01:24:08ZS-EPMC39695082467963410.7448/IAS.17.1.18899