{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["5"],"submitter":["Fabre O"],"pubmed_abstract":["Obesity is associated with chronic low-grade inflammation and oxidative stress that blunt insulin response in its target tissues, leading to insulin resistance (IR). IR is a characteristic feature of type 2 diabetes. Skeletal muscle is responsible for 75% of total insulin-dependent glucose uptake; consequently, skeletal muscle IR is considered to be the primary defect of systemic IR development. Interestingly, some obese people stay insulin-sensitive and metabolically healthy. With the aim of understanding this difference and identifying the mechanisms responsible for insulin sensitivity maintenance/IR development during obesity, we explored the role of the latent endoribonuclease (RNase L) in skeletal muscle cells. RNase L is a regulator of innate immunity, of double-stranded RNA sensors "],"journal":["Cell death & disease"],"pagination":["e1136"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3973244"],"repository":["biostudies-literature"],"pubmed_title":["Defects in TLR3 expression and RNase L activation lead to decreased MnSOD expression and insulin resistance in muscle cells of obese people."],"pmcid":["PMC3973244"],"pubmed_authors":["Breuker C","Kitzmann M","Salehzada T","Amouzou C","Fabre O","Mercier J","Bisbal C"],"additional_accession":[]},"is_claimable":false,"name":"Defects in TLR3 expression and RNase L activation lead to decreased MnSOD expression and insulin resistance in muscle cells of obese people.","description":"Obesity is associated with chronic low-grade inflammation and oxidative stress that blunt insulin response in its target tissues, leading to insulin resistance (IR). IR is a characteristic feature of type 2 diabetes. Skeletal muscle is responsible for 75% of total insulin-dependent glucose uptake; consequently, skeletal muscle IR is considered to be the primary defect of systemic IR development. Interestingly, some obese people stay insulin-sensitive and metabolically healthy. With the aim of understanding this difference and identifying the mechanisms responsible for insulin sensitivity maintenance/IR development during obesity, we explored the role of the latent endoribonuclease (RNase L) in skeletal muscle cells. RNase L is a regulator of innate immunity, of double-stranded RNA sensors ","dates":{"release":"2014-01-01T00:00:00Z","publication":"2014 Mar","modification":"2025-04-20T02:48:58.456Z","creation":"2019-03-27T01:24:19Z"},"accession":"S-EPMC3973244","cross_references":{"pubmed":["24651439"],"doi":["10.1038/cddis.2014.104"]}}