{"database":"biostudies-literature","file_versions":[],"scores":{"citationCount":0,"reanalysisCount":0,"viewCount":60,"searchCount":0},"additional":{"submitter":["Li H"],"funding":["NIGMS NIH HHS"],"pagination":["5425-7"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC397398"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["101(15)"],"pubmed_abstract":["We have examined the use of our bis(sulfonamide) diol ligand (1) in the asymmetric addition of phenyl groups to cyclic alpha,beta-unsaturated ketones. Good to excellent enantioselectivities have been obtained with cyclic enones bearing alkyl substituents in the 2 position (71-97% enantiomeric excess). Furthermore, excellent enantioselectivities have been observed in the asymmetric phenylation of cyclic enones with 2-iodo and 2-bromo substituents. The results of this study broaden the scope of the asymmetric additions to ketones promoted by the titanium catalyst derived from ligand 1."],"journal":["Proceedings of the National Academy of Sciences of the United States of America"],"pubmed_title":["Catalytic asymmetric addition of diphenylzinc to cyclic alpha,beta-unsaturated ketones."],"pmcid":["PMC397398"],"funding_grant_id":["R01 GM058101","GM58101"],"pubmed_authors":["Li H","Walsh PJ","Garcia C"],"view_count":["60"],"additional_accession":[]},"is_claimable":false,"name":"Catalytic asymmetric addition of diphenylzinc to cyclic alpha,beta-unsaturated ketones.","description":"We have examined the use of our bis(sulfonamide) diol ligand (1) in the asymmetric addition of phenyl groups to cyclic alpha,beta-unsaturated ketones. Good to excellent enantioselectivities have been obtained with cyclic enones bearing alkyl substituents in the 2 position (71-97% enantiomeric excess). Furthermore, excellent enantioselectivities have been observed in the asymmetric phenylation of cyclic enones with 2-iodo and 2-bromo substituents. The results of this study broaden the scope of the asymmetric additions to ketones promoted by the titanium catalyst derived from ligand 1.","dates":{"release":"2004-01-01T00:00:00Z","publication":"2004 Apr","modification":"2021-02-21T04:04:51Z","creation":"2019-03-27T00:50:23Z"},"accession":"S-EPMC397398","cross_references":{"pubmed":["15067130"],"doi":["10.1073/pnas.0307119101"]}}