biostudies-literatureUnknown9(4)Ge YZ<h4>Background</h4>Transforming growth factor-beta 1(TGF-β1) is involved in the development of acute rejection (AR) episodes in solid organ transplant recipients; and a number of studies have been conducted to investigate the combined effects of human TGF-β1 gene (TGFB1) +869 T/C and +915 G/C polymorphisms on AR risk. However, the results obtained are inconclusive.<h4>Methods</h4>Eligible studies that investigated the haplotypic association between TGFB1 +869 T/C and +915 G/C polymorphisms and AR risk were comprehensively searched in the PUBMED, EMBASE, China National Knowledge Infrastructure, and Wanfang Database. Statistical analyses were performed by using STATA 12.0 and Review Manager 5.0.<h4>Results</h4>Fourteen eligible studies with 565 AR cases and 1219 non-AR cases were included. OPloS onee93938https://www.ebi.ac.uk/biostudies/studies/S-EPMC3976347biostudies-literatureCombined effects of TGFB1 +869 T/C and +915 G/C polymorphisms on acute rejection risk in solid organ transplant recipients: a systematic review and meta-analysis.PMC3976347Zhu XBLi MHJia RPGao XFLi WCJiang XMGe YZZhu JGTan SJSong QLi LPWu RLu TZfalseCombined effects of TGFB1 +869 T/C and +915 G/C polymorphisms on acute rejection risk in solid organ transplant recipients: a systematic review and meta-analysis.<h4>Background</h4>Transforming growth factor-beta 1(TGF-β1) is involved in the development of acute rejection (AR) episodes in solid organ transplant recipients; and a number of studies have been conducted to investigate the combined effects of human TGF-β1 gene (TGFB1) +869 T/C and +915 G/C polymorphisms on AR risk. However, the results obtained are inconclusive.<h4>Methods</h4>Eligible studies that investigated the haplotypic association between TGFB1 +869 T/C and +915 G/C polymorphisms and AR risk were comprehensively searched in the PUBMED, EMBASE, China National Knowledge Infrastructure, and Wanfang Database. Statistical analyses were performed by using STATA 12.0 and Review Manager 5.0.<h4>Results</h4>Fourteen eligible studies with 565 AR cases and 1219 non-AR cases were included. O2014-01-01T00:00:00Z20142026-05-04T20:49:53.945Z2019-03-26T23:25:33ZS-EPMC39763472470544410.1371/journal.pone.0093938