{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Wang X"],"funding":["NHLBI NIH HHS"],"pagination":["S238-46"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3977692"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["120(11 Suppl)"],"pubmed_abstract":["<h4>Background</h4>Using a swine model of postinfarction left ventricle (LV) remodeling, we investigated marrow-derived, multipotent progenitor cell (MPC) transplantation into hearts with acute myocardial infarction (AMI) via a novel transarterial catheter.<h4>Methods and results</h4>The left anterior descending coronary artery was balloon-occluded after percutaneous transluminal angiography to generate AMI (60-minute no-flow ischemia). The transarterial catheter was then placed in the same coronary artery, and either 50x10(6) MPCs (cell group, n=6) or saline (control, n=6) was injected into the border zone (BZ) myocardium. LV function was assessed by magnetic resonance imaging before AMI and at 1 and 4 weeks after AMI, whereas myocardial energy metabolism was assessed by (31)P-magnetic re"],"journal":["Circulation"],"pubmed_title":["Stem cells for myocardial repair with use of a transarterial catheter."],"pmcid":["PMC3977692"],"funding_grant_id":["R01 HL067828","R01 HL050470-13","R01 HL095077","U01 HL100407","R01 HL095077-01A1","HL50470","HL95077","HL 67828","R01 HL067828-07","R01 HL050470"],"pubmed_authors":["Jameel MN","Swingen C","Zhang J","Mansoor A","Panetta C","Li Q","Qiang X","Wang X"],"additional_accession":[]},"is_claimable":false,"name":"Stem cells for myocardial repair with use of a transarterial catheter.","description":"<h4>Background</h4>Using a swine model of postinfarction left ventricle (LV) remodeling, we investigated marrow-derived, multipotent progenitor cell (MPC) transplantation into hearts with acute myocardial infarction (AMI) via a novel transarterial catheter.<h4>Methods and results</h4>The left anterior descending coronary artery was balloon-occluded after percutaneous transluminal angiography to generate AMI (60-minute no-flow ischemia). The transarterial catheter was then placed in the same coronary artery, and either 50x10(6) MPCs (cell group, n=6) or saline (control, n=6) was injected into the border zone (BZ) myocardium. LV function was assessed by magnetic resonance imaging before AMI and at 1 and 4 weeks after AMI, whereas myocardial energy metabolism was assessed by (31)P-magnetic re","dates":{"release":"2009-01-01T00:00:00Z","publication":"2009 Sep","modification":"2025-04-04T00:03:25.086Z","creation":"2019-03-27T01:24:31Z"},"accession":"S-EPMC3977692","cross_references":{"pubmed":["19752374"],"doi":["10.1161/circulationaha.109.885236","10.1161/CIRCULATIONAHA.109.885236"]}}