biostudies-literatureWang XNHLBI NIH HHSS238-46https://www.ebi.ac.uk/biostudies/studies/S-EPMC3977692biostudies-literatureUnknown120(11 Suppl)<h4>Background</h4>Using a swine model of postinfarction left ventricle (LV) remodeling, we investigated marrow-derived, multipotent progenitor cell (MPC) transplantation into hearts with acute myocardial infarction (AMI) via a novel transarterial catheter.<h4>Methods and results</h4>The left anterior descending coronary artery was balloon-occluded after percutaneous transluminal angiography to generate AMI (60-minute no-flow ischemia). The transarterial catheter was then placed in the same coronary artery, and either 50x10(6) MPCs (cell group, n=6) or saline (control, n=6) was injected into the border zone (BZ) myocardium. LV function was assessed by magnetic resonance imaging before AMI and at 1 and 4 weeks after AMI, whereas myocardial energy metabolism was assessed by (31)P-magnetic reCirculationStem cells for myocardial repair with use of a transarterial catheter.PMC3977692R01 HL067828R01 HL050470-13R01 HL095077U01 HL100407R01 HL095077-01A1HL50470HL95077HL 67828R01 HL067828-07R01 HL050470Jameel MNSwingen CZhang JMansoor APanetta CLi QQiang XWang XfalseStem cells for myocardial repair with use of a transarterial catheter.<h4>Background</h4>Using a swine model of postinfarction left ventricle (LV) remodeling, we investigated marrow-derived, multipotent progenitor cell (MPC) transplantation into hearts with acute myocardial infarction (AMI) via a novel transarterial catheter.<h4>Methods and results</h4>The left anterior descending coronary artery was balloon-occluded after percutaneous transluminal angiography to generate AMI (60-minute no-flow ischemia). The transarterial catheter was then placed in the same coronary artery, and either 50x10(6) MPCs (cell group, n=6) or saline (control, n=6) was injected into the border zone (BZ) myocardium. LV function was assessed by magnetic resonance imaging before AMI and at 1 and 4 weeks after AMI, whereas myocardial energy metabolism was assessed by (31)P-magnetic re2009-01-01T00:00:00Z2009 Sep2025-04-04T00:03:25.086Z2019-03-27T01:24:31ZS-EPMC39776921975237410.1161/circulationaha.109.88523610.1161/CIRCULATIONAHA.109.885236