{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["9(4)"],"submitter":["Su SS"],"pubmed_abstract":["Background & aims
The cellular immunity has a profound impact on the status of hepatitis C virus (HCV) infection. However, the response of cellular immunity on the virological response in patients with antiviral treatment remains largely unclear. We aimed to clarify the response of peripheral T cells and monocytes in chronic hepatitis C patients with antiviral treatment.Methods
Patients with chronic hepatitis C were treated either with interferon alpha-2b plus ribavirin (n = 37) or with pegylated interferon alpha-2a plus ribavirin (n = 33) for up to 24 weeks. Frequencies of peripheral regulatory T-cells (Tregs), programmed death-1 (PD-1) expressing CD4+ T-cells or CD8+ T-cells and toll-like receptor (TLR) 3 expressing CD14+ monocytes were evaluated by flow cytometry in pati"],"journal":["PloS one"],"pagination":["e93620"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3977904"],"repository":["biostudies-literature"],"pubmed_title":["Regulatory phenotype, PD-1 and TLR3 expression in T cells and monocytes from HCV patients undergoing antiviral therapy: a randomized clinical trial."],"pmcid":["PMC3977904"],"pubmed_authors":["Kong LB","He H","Zhang YG","Zheng HW","Su SS","Nan YM","Zhao SX","Yu J","Wang RQ","Sun DX"],"additional_accession":[]},"is_claimable":false,"name":"Regulatory phenotype, PD-1 and TLR3 expression in T cells and monocytes from HCV patients undergoing antiviral therapy: a randomized clinical trial.","description":"Background & aims
The cellular immunity has a profound impact on the status of hepatitis C virus (HCV) infection. However, the response of cellular immunity on the virological response in patients with antiviral treatment remains largely unclear. We aimed to clarify the response of peripheral T cells and monocytes in chronic hepatitis C patients with antiviral treatment.Methods
Patients with chronic hepatitis C were treated either with interferon alpha-2b plus ribavirin (n = 37) or with pegylated interferon alpha-2a plus ribavirin (n = 33) for up to 24 weeks. Frequencies of peripheral regulatory T-cells (Tregs), programmed death-1 (PD-1) expressing CD4+ T-cells or CD8+ T-cells and toll-like receptor (TLR) 3 expressing CD14+ monocytes were evaluated by flow cytometry in pati","dates":{"release":"2014-01-01T00:00:00Z","publication":"2014","modification":"2026-05-07T00:51:07.993Z","creation":"2019-03-26T23:25:34Z"},"accession":"S-EPMC3977904","cross_references":{"pubmed":["24709775"],"doi":["10.1371/journal.pone.0093620"]}}