{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zhang Y"],"funding":["NIDA NIH HHS"],"pagination":["322-9"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3979702"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["63(2)"],"pubmed_abstract":["<h4>Unlabelled</h4>Relapse is a serious problem for the effective treatment of cocaine addiction.<h4>Rationale</h4>Examining cocaine re-exposure-induced behavioral and neurobiological alterations following chronic escalating-dose binge cocaine administration and withdrawal may provide insight into the neurobiological basis of cocaine relapse.<h4>Objectives</h4>Our goal was to determine how exposure to chronic escalating-dose cocaine affects development of subsequent cocaine-induced conditioned place preference (CPP) and changes in endogenous opioid systems.<h4>Methods</h4>Mice were injected with either escalating-dose binge cocaine (15-30 mg/kg/injection × 3/day) or saline for 14-days and conditioned with 15 mg/kg of cocaine or saline (once per day for 10-days), starting either 1 or 14-day"],"journal":["Neuropharmacology"],"pubmed_title":["Effects of withdrawal from chronic escalating-dose binge cocaine on conditioned place preference to cocaine and striatal preproenkephalin mRNA in C57BL/6J mice."],"pmcid":["PMC3979702"],"funding_grant_id":["P60 DA005130","P60-DA05130"],"pubmed_authors":["Butelman ER","Kreek MJ","Zhang Y","Ho A","Schlussman SD"],"additional_accession":[]},"is_claimable":false,"name":"Effects of withdrawal from chronic escalating-dose binge cocaine on conditioned place preference to cocaine and striatal preproenkephalin mRNA in C57BL/6J mice.","description":"<h4>Unlabelled</h4>Relapse is a serious problem for the effective treatment of cocaine addiction.<h4>Rationale</h4>Examining cocaine re-exposure-induced behavioral and neurobiological alterations following chronic escalating-dose binge cocaine administration and withdrawal may provide insight into the neurobiological basis of cocaine relapse.<h4>Objectives</h4>Our goal was to determine how exposure to chronic escalating-dose cocaine affects development of subsequent cocaine-induced conditioned place preference (CPP) and changes in endogenous opioid systems.<h4>Methods</h4>Mice were injected with either escalating-dose binge cocaine (15-30 mg/kg/injection × 3/day) or saline for 14-days and conditioned with 15 mg/kg of cocaine or saline (once per day for 10-days), starting either 1 or 14-day","dates":{"release":"2012-01-01T00:00:00Z","publication":"2012 Aug","modification":"2025-04-19T14:55:26.237Z","creation":"2019-03-27T01:24:37Z"},"accession":"S-EPMC3979702","cross_references":{"pubmed":["22504589"],"doi":["10.1016/j.neuropharm.2012.03.021"]}}