biostudies-literatureZhang YNIDA NIH HHS322-9https://www.ebi.ac.uk/biostudies/studies/S-EPMC3979702biostudies-literatureUnknown63(2)<h4>Unlabelled</h4>Relapse is a serious problem for the effective treatment of cocaine addiction.<h4>Rationale</h4>Examining cocaine re-exposure-induced behavioral and neurobiological alterations following chronic escalating-dose binge cocaine administration and withdrawal may provide insight into the neurobiological basis of cocaine relapse.<h4>Objectives</h4>Our goal was to determine how exposure to chronic escalating-dose cocaine affects development of subsequent cocaine-induced conditioned place preference (CPP) and changes in endogenous opioid systems.<h4>Methods</h4>Mice were injected with either escalating-dose binge cocaine (15-30 mg/kg/injection × 3/day) or saline for 14-days and conditioned with 15 mg/kg of cocaine or saline (once per day for 10-days), starting either 1 or 14-dayNeuropharmacologyEffects of withdrawal from chronic escalating-dose binge cocaine on conditioned place preference to cocaine and striatal preproenkephalin mRNA in C57BL/6J mice.PMC3979702P60 DA005130P60-DA05130Butelman ERKreek MJZhang YHo ASchlussman SDfalseEffects of withdrawal from chronic escalating-dose binge cocaine on conditioned place preference to cocaine and striatal preproenkephalin mRNA in C57BL/6J mice.<h4>Unlabelled</h4>Relapse is a serious problem for the effective treatment of cocaine addiction.<h4>Rationale</h4>Examining cocaine re-exposure-induced behavioral and neurobiological alterations following chronic escalating-dose binge cocaine administration and withdrawal may provide insight into the neurobiological basis of cocaine relapse.<h4>Objectives</h4>Our goal was to determine how exposure to chronic escalating-dose cocaine affects development of subsequent cocaine-induced conditioned place preference (CPP) and changes in endogenous opioid systems.<h4>Methods</h4>Mice were injected with either escalating-dose binge cocaine (15-30 mg/kg/injection × 3/day) or saline for 14-days and conditioned with 15 mg/kg of cocaine or saline (once per day for 10-days), starting either 1 or 14-day2012-01-01T00:00:00Z2012 Aug2025-04-19T14:55:26.237Z2019-03-27T01:24:37ZS-EPMC39797022250458910.1016/j.neuropharm.2012.03.021