{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Rubio AE"],"funding":["NIAID NIH HHS"],"pagination":["e92084"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3984079"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["9(4)"],"pubmed_abstract":["The HIV-1 epidemic in South America is dominated by pure subtypes (mostly B and C) and more than 7 BF and BC recombinant forms. In Argentina, circulating recombinant forms (CRFs) comprised of subtypes B and F make up more than 50% of HIV infections. For this study, 28 HIV-1 primary isolates were obtained from patients in Buenos Aires, Argentina and initially classified into subtype B (n = 9, 32.1%), C (n = 1, 3.6%), and CRFs (n = 18, 64.3%) using partial pol and vpu-env sequences, which proved to be inconsistent and inaccurate for these phylogenetic analyses. Near full length genome sequences of these primary HIV-1 isolates revealed that nearly all intersubtype BF recombination sites were unique and countered previous \"CRF\" B/F classifications. The majority of these Argentinean HIV-1 isola"],"journal":["PloS one"],"pubmed_title":["Similar replicative fitness is shared by the subtype B and unique BF recombinant HIV-1 isolates that dominate the epidemic in Argentina."],"pmcid":["PMC3984079"],"funding_grant_id":["AI36219","R01 AI049170","AI49170","R56 AI049170","P30 AI036219","R21 AI049170"],"pubmed_authors":["Rubio AE","Arts EJ","Reyes-Rodriguez AL","Salomon H","Tebit DM","Abraha A","Carpenter CA","Troyer RM"],"additional_accession":[]},"is_claimable":false,"name":"Similar replicative fitness is shared by the subtype B and unique BF recombinant HIV-1 isolates that dominate the epidemic in Argentina.","description":"The HIV-1 epidemic in South America is dominated by pure subtypes (mostly B and C) and more than 7 BF and BC recombinant forms. In Argentina, circulating recombinant forms (CRFs) comprised of subtypes B and F make up more than 50% of HIV infections. For this study, 28 HIV-1 primary isolates were obtained from patients in Buenos Aires, Argentina and initially classified into subtype B (n = 9, 32.1%), C (n = 1, 3.6%), and CRFs (n = 18, 64.3%) using partial pol and vpu-env sequences, which proved to be inconsistent and inaccurate for these phylogenetic analyses. Near full length genome sequences of these primary HIV-1 isolates revealed that nearly all intersubtype BF recombination sites were unique and countered previous \"CRF\" B/F classifications. The majority of these Argentinean HIV-1 isola","dates":{"release":"2014-01-01T00:00:00Z","publication":"2014","modification":"2026-04-07T21:21:17.49Z","creation":"2019-03-26T23:25:39Z"},"accession":"S-EPMC3984079","cross_references":{"pubmed":["24727861"],"doi":["10.1371/journal.pone.0092084"]}}