biostudies-literatureSkouta RNICHD NIH HHSNIDDK NIH HHSNCRR NIH HHSNCI NIH HHSNINDS NIH HHSNIGMS NIH HHS4551-6https://www.ebi.ac.uk/biostudies/studies/S-EPMC3985476biostudies-literatureUnknown136(12)Ferrostatin-1 (Fer-1) inhibits ferroptosis, a form of regulated, oxidative, nonapoptotic cell death. We found that Fer-1 inhibited cell death in cellular models of Huntington's disease (HD), periventricular leukomalacia (PVL), and kidney dysfunction; Fer-1 inhibited lipid peroxidation, but not mitochondrial reactive oxygen species formation or lysosomal membrane permeability. We developed a mechanistic model to explain the activity of Fer-1, which guided the development of ferrostatins with improved properties. These studies suggest numerous therapeutic uses for ferrostatins, and that lipid peroxidation mediates diverse disease phenotypes.Journal of the American Chemical SocietyFerrostatins inhibit oxidative lipid damage and cell death in diverse disease models.PMC3985476R01 GM085081DK34275R01 DK034275HD18655R01 CA097061R01CA097061R56 DK0342751S10RR025431-01A1K99 CA1665171K99CA166517-01P30 HD018655NS066019R00 CA166517R01 NS066019R01 CA161061R01GM085081Skouta RStockwell BROrman MDixon SJLinkermann ARosenberg PAWang JLo DCShimada KDunn DEWeinberg JMfalseFerrostatins inhibit oxidative lipid damage and cell death in diverse disease models.Ferrostatin-1 (Fer-1) inhibits ferroptosis, a form of regulated, oxidative, nonapoptotic cell death. We found that Fer-1 inhibited cell death in cellular models of Huntington's disease (HD), periventricular leukomalacia (PVL), and kidney dysfunction; Fer-1 inhibited lipid peroxidation, but not mitochondrial reactive oxygen species formation or lysosomal membrane permeability. We developed a mechanistic model to explain the activity of Fer-1, which guided the development of ferrostatins with improved properties. These studies suggest numerous therapeutic uses for ferrostatins, and that lipid peroxidation mediates diverse disease phenotypes.2014-01-01T00:00:00Z2014 Mar2021-02-21T08:20:24Z2019-03-27T01:24:53ZS-EPMC39854762459286610.1021/ja411006a