{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Louis ED"],"funding":["NCATS NIH HHS","NINDS NIH HHS"],"pagination":["e004626"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3987722"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["4(4)"],"pubmed_abstract":["<h4>Objective</h4>Few studies have attempted to estimate the rate of decline over time in essential tremor (ET). The study objectives were to: (1) measure change, deriving a single summary measure for the entire group, and relate it to a commonly used clinical rating scale (ie, yearly change in points on that scale); (2) to assess change as a function of baseline clinical characteristics and (3) to answer the basic clinical question-is change perceptible/obvious during the follow-up of ET cases?<h4>Setting</h4>Prospective collection of longitudinal data on ET cases enrolled in a study of the environmental epidemiology of ET at Columbia University Medical Center (2000-2008).<h4>Participants</h4>116 unselected ET cases.<h4>Interventions</h4>Each case underwent the same evaluation at baseline and during one follow-up visit (mean follow-up interval (range)=5.8 (1.4-12.4) years).<h4>Primary and secondary outcome measures</h4>We assessed tremor during a commonly affected daily activity-drawing (ie, spirography), quantifying tremor using a simple, standardised 10-point rating scale developed by Bain and Findley.<h4>Results</h4>The Bain and Findley spiral score increased at an average rate of 0.12±0.23 points per year (maximum=1 point/year). In cases who had been followed for ≥5 years, the change was obvious-a blinded neurologist was able to correctly order their spirals (baseline vs follow-up) in three-fourth of cases. The rate of change was higher in cases with versus without familial ET (p=0.01).<h4>Conclusions</h4>Tremor in ET is slowly progressive; yet in the majority of cases, a clear difference in handwritten spirals was visible with a follow-up interval of five or more years. There may be differences between familial and non-familial ET in the rate of progression. These clinical data are intended to aid in the prognostic discussions that treating physicians have with their patients with ET."],"journal":["BMJ open"],"pubmed_title":["Shaky drawing: what is the rate of decline during prospective follow-up of essential tremor?"],"pmcid":["PMC3987722"],"funding_grant_id":["UL1 TR000040","R01 NS039422","UL1TR000040"],"pubmed_authors":["Louis ED","Gillman A","Michalec M"],"additional_accession":[]},"is_claimable":false,"name":"Shaky drawing: what is the rate of decline during prospective follow-up of essential tremor?","description":"<h4>Objective</h4>Few studies have attempted to estimate the rate of decline over time in essential tremor (ET). The study objectives were to: (1) measure change, deriving a single summary measure for the entire group, and relate it to a commonly used clinical rating scale (ie, yearly change in points on that scale); (2) to assess change as a function of baseline clinical characteristics and (3) to answer the basic clinical question-is change perceptible/obvious during the follow-up of ET cases?<h4>Setting</h4>Prospective collection of longitudinal data on ET cases enrolled in a study of the environmental epidemiology of ET at Columbia University Medical Center (2000-2008).<h4>Participants</h4>116 unselected ET cases.<h4>Interventions</h4>Each case underwent the same evaluation at baseline and during one follow-up visit (mean follow-up interval (range)=5.8 (1.4-12.4) years).<h4>Primary and secondary outcome measures</h4>We assessed tremor during a commonly affected daily activity-drawing (ie, spirography), quantifying tremor using a simple, standardised 10-point rating scale developed by Bain and Findley.<h4>Results</h4>The Bain and Findley spiral score increased at an average rate of 0.12±0.23 points per year (maximum=1 point/year). In cases who had been followed for ≥5 years, the change was obvious-a blinded neurologist was able to correctly order their spirals (baseline vs follow-up) in three-fourth of cases. The rate of change was higher in cases with versus without familial ET (p=0.01).<h4>Conclusions</h4>Tremor in ET is slowly progressive; yet in the majority of cases, a clear difference in handwritten spirals was visible with a follow-up interval of five or more years. There may be differences between familial and non-familial ET in the rate of progression. These clinical data are intended to aid in the prognostic discussions that treating physicians have with their patients with ET.","dates":{"release":"2014-01-01T00:00:00Z","publication":"2014 Apr","modification":"2024-11-13T23:48:24.921Z","creation":"2019-03-27T01:25:05Z"},"accession":"S-EPMC3987722","cross_references":{"pubmed":["24722199"],"doi":["10.1136/bmjopen-2013-004626"]}}