{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Lv H"],"funding":["NICHD NIH HHS","NCATS NIH HHS","NIDDK NIH HHS","NCRR NIH HHS","NHLBI NIH HHS"],"pagination":["1397-404"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3993901"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["13(3)"],"pubmed_abstract":["Bacterial siderophores are a group of chemically diverse, virulence-associated secondary metabolites whose expression exerts metabolic costs. A combined bacterial genetic and metabolomic approach revealed differential metabolomic impacts associated with biosynthesis of different siderophore structural families. Despite myriad genetic differences, the metabolome of a cheater mutant lacking a single set of siderophore biosynthetic genes more closely approximate that of a non-pathogenic K12 strain than its isogenic, uropathogen parent strain. Siderophore types associated with greater metabolomic perturbations are less common among human isolates, suggesting that metabolic costs influence success in a human population. Although different siderophores share a common iron acquisition function, our analysis shows how a metabolomic approach can distinguish their relative metabolic impacts in E. coli."],"journal":["Journal of proteome research"],"pubmed_title":["Metabolomic analysis of siderophore cheater mutants reveals metabolic costs of expression in uropathogenic Escherichia coli."],"pmcid":["PMC3993901"],"funding_grant_id":["P50 DK064540","DK064540","HD001459-09","UL1 RR024992","HL101263-01","P30 HL101263","UL1 TR000448","K12 HD001459"],"pubmed_authors":["Henderson JP","Lv H","Hung CS"],"additional_accession":[]},"is_claimable":false,"name":"Metabolomic analysis of siderophore cheater mutants reveals metabolic costs of expression in uropathogenic Escherichia coli.","description":"Bacterial siderophores are a group of chemically diverse, virulence-associated secondary metabolites whose expression exerts metabolic costs. A combined bacterial genetic and metabolomic approach revealed differential metabolomic impacts associated with biosynthesis of different siderophore structural families. Despite myriad genetic differences, the metabolome of a cheater mutant lacking a single set of siderophore biosynthetic genes more closely approximate that of a non-pathogenic K12 strain than its isogenic, uropathogen parent strain. Siderophore types associated with greater metabolomic perturbations are less common among human isolates, suggesting that metabolic costs influence success in a human population. Although different siderophores share a common iron acquisition function, our analysis shows how a metabolomic approach can distinguish their relative metabolic impacts in E. coli.","dates":{"release":"2014-01-01T00:00:00Z","publication":"2014 Mar","modification":"2025-04-18T19:34:34.744Z","creation":"2019-03-27T01:26:49Z"},"accession":"S-EPMC3993901","cross_references":{"pubmed":["24476533"],"doi":["10.1021/pr4009749"]}}