{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Hartung AM"],"funding":["Intramural NIH HHS","NIDA NIH HHS","National Institutes of Health"],"pagination":["311-9"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3993902"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["77(2)"],"pubmed_abstract":["The natural stilbene pawhuskin A has been shown to function as an opioid receptor antagonist, with preferential binding to the κ receptor. This finding encouraged assembly of a set of analogues to probe the importance of key structural features. Assays on these compounds determined that one (compound 29) shows potent opioid receptor binding activity and significantly improved selectivity for the κ receptor. These studies begin to illuminate the structural features of these non-nitrogenous opioid receptor antagonists that are required for activity."],"journal":["Journal of natural products"],"pubmed_title":["Stilbenes as κ-selective, non-nitrogenous opioid receptor antagonists."],"pmcid":["PMC3993902"],"funding_grant_id":["DA02-6573","R03 DA026573"],"pubmed_authors":["Hartung AM","Beutler JA","Neighbors JD","Wiemer DF","Navarro HA"],"additional_accession":[]},"is_claimable":false,"name":"Stilbenes as κ-selective, non-nitrogenous opioid receptor antagonists.","description":"The natural stilbene pawhuskin A has been shown to function as an opioid receptor antagonist, with preferential binding to the κ receptor. This finding encouraged assembly of a set of analogues to probe the importance of key structural features. Assays on these compounds determined that one (compound 29) shows potent opioid receptor binding activity and significantly improved selectivity for the κ receptor. These studies begin to illuminate the structural features of these non-nitrogenous opioid receptor antagonists that are required for activity.","dates":{"release":"2014-01-01T00:00:00Z","publication":"2014 Feb","modification":"2025-04-18T19:34:36.859Z","creation":"2019-03-27T01:26:49Z"},"accession":"S-EPMC3993902","cross_references":{"pubmed":["24456556"],"doi":["10.1021/np4009046"]}}