biostudies-literatureUnknown3Zhang HPSpecific immunotherapy (SIT) is the only specific remedy for the treatment of allergic diseases currently. B cells are important immune cells in the immunity. The role of B cells in immune regulatory activities has not been fully understood yet. This study aims to elucidate the role of the thrombospondin (TSP)1-producing B cells in the immune regulatory role of SIT. The results showed that after SIT, the frequency of CD35(+) B cells was increased in the intestine of mice with food allergy. The CD35(+) B cells expressed TSP1 after exposure to specific antigens. Co-culture with the TSP1-producing CD35(+) B cells decreased the levels of CD80/CD86 in dendritic cells; the cells convert naïve CD4(+) T cells to regulatory T cells to inhibit allergic inflammation in the intestine.Scientific reports3345https://www.ebi.ac.uk/biostudies/studies/S-EPMC4002291biostudies-literatureTSP1-producing B cells show immune regulatory property and suppress allergy-related mucosal inflammation.PMC4002291Jiang JYang GLiu JGeng XRLiu ZQLiu ZGZhang HPMo LYang PCWu YfalseTSP1-producing B cells show immune regulatory property and suppress allergy-related mucosal inflammation.Specific immunotherapy (SIT) is the only specific remedy for the treatment of allergic diseases currently. B cells are important immune cells in the immunity. The role of B cells in immune regulatory activities has not been fully understood yet. This study aims to elucidate the role of the thrombospondin (TSP)1-producing B cells in the immune regulatory role of SIT. The results showed that after SIT, the frequency of CD35(+) B cells was increased in the intestine of mice with food allergy. The CD35(+) B cells expressed TSP1 after exposure to specific antigens. Co-culture with the TSP1-producing CD35(+) B cells decreased the levels of CD80/CD86 in dendritic cells; the cells convert naïve CD4(+) T cells to regulatory T cells to inhibit allergic inflammation in the intestine.2013-01-01T00:00:00Z2013 Nov2024-11-13T11:11:58.847Z2019-03-27T01:27:14ZS-EPMC40022912473621310.1038/srep03345