biostudies-literatureUnknown48(5)Fillet AMWe described the natural polymorphism of cytomegalovirus DNA polymerase in 42 unrelated isolates susceptible to ganciclovir, foscarnet, and cidofovir. All variations, including an eight-amino-acid deletion, were located between domains delta-C and II and between domains III and I, suggesting that these specific residues are not involved in enzymatic functions.Antimicrobial agents and chemotherapy1865-8https://www.ebi.ac.uk/biostudies/studies/S-EPMC400574biostudies-literatureNatural polymorphism of cytomegalovirus DNA polymerase lies in two nonconserved regions located between domains delta-C and II and between domains III and I.PMC400574Gouarin SGourlain KMazeron MCAlain SChampier GNajioullah FCarquin JAuray LHouhou NGarrigue IDucancelle AFillet AMImbert BMThouvenot DfalseNatural polymorphism of cytomegalovirus DNA polymerase lies in two nonconserved regions located between domains delta-C and II and between domains III and I.We described the natural polymorphism of cytomegalovirus DNA polymerase in 42 unrelated isolates susceptible to ganciclovir, foscarnet, and cidofovir. All variations, including an eight-amino-acid deletion, were located between domains delta-C and II and between domains III and I, suggesting that these specific residues are not involved in enzymatic functions.2004-01-01T00:00:00Z2004 May2025-04-26T04:25:29.377Z2019-03-27T00:50:24ZS-EPMC4005741510514510.1128/aac.48.5.1865-1868.200410.1128/AAC.48.5.1865-1868.2004