{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Mitzel DN"],"funding":["NIA NIH HHS"],"pagination":["4273-83"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4007355"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["192(9)"],"pubmed_abstract":["Pneumococcal infections remain a leading cause of death in persons ≥ 65 y of age. Recent reports have illustrated detrimental changes in the endoplasmic reticulum stress response or unfolded protein response in aging and age-related diseases; however, the relationship between aging, the unfolded protein response, and innate immune responses to Streptococcus pneumoniae has not been fully elucidated. Our results illustrate that stimulator of IFN genes-mediated production of IFN-β during S. pneumoniae infection is decreased in aged hosts. Enhanced endoplasmic reticulum stress in response to S. pneumoniae augmented inositol-requiring protein 1/X-box binding protein 1-mediated production of autophagy-related gene 9 (Atg9a). Knockdown of Atg9a or treatment with gemcitabine HCl resulted in enhanc"],"journal":["Journal of immunology (Baltimore, Md. : 1950)"],"pubmed_title":["Age-enhanced endoplasmic reticulum stress contributes to increased Atg9A inhibition of STING-mediated IFN-β production during Streptococcus pneumoniae infection."],"pmcid":["PMC4007355"],"funding_grant_id":["K01 AG034999","L30 AG043118","R21AG044755","K01AG034999","R21 AG044755"],"pubmed_authors":["Liu Y","Mitzel DN","Shirali AC","Lowry V","Stout-Delgado HW"],"additional_accession":[]},"is_claimable":false,"name":"Age-enhanced endoplasmic reticulum stress contributes to increased Atg9A inhibition of STING-mediated IFN-β production during Streptococcus pneumoniae infection.","description":"Pneumococcal infections remain a leading cause of death in persons ≥ 65 y of age. Recent reports have illustrated detrimental changes in the endoplasmic reticulum stress response or unfolded protein response in aging and age-related diseases; however, the relationship between aging, the unfolded protein response, and innate immune responses to Streptococcus pneumoniae has not been fully elucidated. Our results illustrate that stimulator of IFN genes-mediated production of IFN-β during S. pneumoniae infection is decreased in aged hosts. Enhanced endoplasmic reticulum stress in response to S. pneumoniae augmented inositol-requiring protein 1/X-box binding protein 1-mediated production of autophagy-related gene 9 (Atg9a). Knockdown of Atg9a or treatment with gemcitabine HCl resulted in enhanc","dates":{"release":"2014-01-01T00:00:00Z","publication":"2014 May","modification":"2025-04-21T18:58:48.525Z","creation":"2019-03-27T01:27:27Z"},"accession":"S-EPMC4007355","cross_references":{"pubmed":["24670807"],"doi":["10.4049/jimmunol.1303090"]}}