{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["1(2)"],"submitter":["Zeng F"],"pubmed_abstract":["A series of imidazo[1,2-b]pyridazine derivatives were synthesized and evaluated for binding to amyloid plaques in vitro using synthetic aggregates of Aβ1-40. Binding affinities of these compounds were found to range from 11.0 to >1000 nM, depending on the various substitution patterns in the 6-position and 2-position. 2-(4'-Dimethylaminophenyl)-6-(methylthio)imidazo[1,2-b]pyridazine (4) showed high binding affinity (K i = 11.0 nM) and might be useful for the development of novel positron emission tomography radiotracers for imaging Aβ plaques."],"journal":["ACS medicinal chemistry letters"],"pagination":["80-4"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4007799"],"repository":["biostudies-literature"],"pubmed_title":["Synthesis and In Vitro Evaluation of Imidazo[1,2-b]pyridazines as Ligands for β-Amyloid Plaques."],"pmcid":["PMC4007799"],"pubmed_authors":["Levey AI","Goodman MM","Alagille D","Zeng F","Tamagnan GD","Ciliax BJ"],"additional_accession":[]},"is_claimable":false,"name":"Synthesis and In Vitro Evaluation of Imidazo[1,2-b]pyridazines as Ligands for β-Amyloid Plaques.","description":"A series of imidazo[1,2-b]pyridazine derivatives were synthesized and evaluated for binding to amyloid plaques in vitro using synthetic aggregates of Aβ1-40. Binding affinities of these compounds were found to range from 11.0 to >1000 nM, depending on the various substitution patterns in the 6-position and 2-position. 2-(4'-Dimethylaminophenyl)-6-(methylthio)imidazo[1,2-b]pyridazine (4) showed high binding affinity (K i = 11.0 nM) and might be useful for the development of novel positron emission tomography radiotracers for imaging Aβ plaques.","dates":{"release":"2010-01-01T00:00:00Z","publication":"2010 May","modification":"2025-04-04T22:38:39.811Z","creation":"2019-03-27T01:27:29Z"},"accession":"S-EPMC4007799","cross_references":{"pubmed":["24900181"],"doi":["10.1021/ml100005j"]}}