{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["1(4)"],"submitter":["Ding D"],"pubmed_abstract":["We report the discovery of benzoxaborole antitrypanosomal agents and their structure-activity relationships on central linkage groups and different substitution patterns in the sulfur-linked series. The compounds showed in vitro growth inhibition IC50 values as low as 0.02 μg/mL and in vivo efficacy in acute murine infection models against Tryapnosoma brucei."],"journal":["ACS medicinal chemistry letters"],"pagination":["165-9"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4007846"],"repository":["biostudies-literature"],"pubmed_title":["Discovery of novel benzoxaborole-based potent antitrypanosomal agents."],"pmcid":["PMC4007846"],"pubmed_authors":["Hernandez V","Xia Y","Meng Q","Yarlett N","Ding D","Jacobs RT","Ang KH","Zhao Y","Nare B","Chen D","Xie D","Abdulla M","Zhang YK","McKerrow JH","Ratnam J","Freund Y","Zhou H","Bacchi CJ","Plattner JJ"],"additional_accession":[]},"is_claimable":false,"name":"Discovery of novel benzoxaborole-based potent antitrypanosomal agents.","description":"We report the discovery of benzoxaborole antitrypanosomal agents and their structure-activity relationships on central linkage groups and different substitution patterns in the sulfur-linked series. The compounds showed in vitro growth inhibition IC50 values as low as 0.02 μg/mL and in vivo efficacy in acute murine infection models against Tryapnosoma brucei.","dates":{"release":"2010-01-01T00:00:00Z","publication":"2010 Jul","modification":"2025-04-05T10:37:18.713Z","creation":"2019-03-27T01:27:29Z"},"accession":"S-EPMC4007846","cross_references":{"pubmed":["24900190"],"doi":["10.1021/ml100013s"]}}