biostudies-literatureUnknown1(4)Ding DWe report the discovery of benzoxaborole antitrypanosomal agents and their structure-activity relationships on central linkage groups and different substitution patterns in the sulfur-linked series. The compounds showed in vitro growth inhibition IC50 values as low as 0.02 μg/mL and in vivo efficacy in acute murine infection models against Tryapnosoma brucei.ACS medicinal chemistry letters165-9https://www.ebi.ac.uk/biostudies/studies/S-EPMC4007846biostudies-literatureDiscovery of novel benzoxaborole-based potent antitrypanosomal agents.PMC4007846Hernandez VXia YMeng QYarlett NDing DJacobs RTAng KHZhao YNare BChen DXie DAbdulla MZhang YKMcKerrow JHRatnam JFreund YZhou HBacchi CJPlattner JJfalseDiscovery of novel benzoxaborole-based potent antitrypanosomal agents.We report the discovery of benzoxaborole antitrypanosomal agents and their structure-activity relationships on central linkage groups and different substitution patterns in the sulfur-linked series. The compounds showed in vitro growth inhibition IC50 values as low as 0.02 μg/mL and in vivo efficacy in acute murine infection models against Tryapnosoma brucei.2010-01-01T00:00:00Z2010 Jul2025-04-05T10:37:18.713Z2019-03-27T01:27:29ZS-EPMC40078462490019010.1021/ml100013s