{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Huynh NT"],"funding":["NHLBI NIH HHS"],"pagination":["58"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4010762"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["5"],"pubmed_abstract":["<h4>Introduction</h4>Obstructive sleep apnea syndrome (OSAS) is a frequent breathing disorder occurring during sleep that is characterized by recurrent hypoxic episodes and sleep fragmentation. It remains unclear whether OSAS leads to structural brain changes, and if so, in which brain regions. Brain region-specific gray and white matter volume (GMV and WMV) changes can be measured with voxel-based morphometry (VBM). The aims of this study were to use VBM to analyze GMV and WMV in untreated OSAS patients compared to healthy controls (HC); examine the impact of OSAS-related variables (nocturnal hypoxemia duration and sleep fragmentation index) on GMV and WMV; and assess the effects of therapeutic vs. sham continuous positive airway pressure (CPAP) treatment. We discuss our results in light "],"journal":["Frontiers in neurology"],"pubmed_title":["Volumetric Brain Morphometry Changes in Patients with Obstructive Sleep Apnea Syndrome: Effects of CPAP Treatment and Literature Review."],"pmcid":["PMC4010762"],"funding_grant_id":["U01 HL068060"],"pubmed_authors":["Kushida CA","Huynh NT","Guilleminault C","Prilipko O"],"additional_accession":[]},"is_claimable":false,"name":"Volumetric Brain Morphometry Changes in Patients with Obstructive Sleep Apnea Syndrome: Effects of CPAP Treatment and Literature Review.","description":"<h4>Introduction</h4>Obstructive sleep apnea syndrome (OSAS) is a frequent breathing disorder occurring during sleep that is characterized by recurrent hypoxic episodes and sleep fragmentation. It remains unclear whether OSAS leads to structural brain changes, and if so, in which brain regions. Brain region-specific gray and white matter volume (GMV and WMV) changes can be measured with voxel-based morphometry (VBM). The aims of this study were to use VBM to analyze GMV and WMV in untreated OSAS patients compared to healthy controls (HC); examine the impact of OSAS-related variables (nocturnal hypoxemia duration and sleep fragmentation index) on GMV and WMV; and assess the effects of therapeutic vs. sham continuous positive airway pressure (CPAP) treatment. We discuss our results in light ","dates":{"release":"2014-01-01T00:00:00Z","publication":"2014","modification":"2025-04-19T14:02:06.439Z","creation":"2019-03-27T01:27:35Z"},"accession":"S-EPMC4010762","cross_references":{"pubmed":["24808886"],"doi":["10.3389/fneur.2014.00058"]}}