{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["9(5)"],"submitter":["Jullig M"],"pubmed_abstract":["<h4>Background</h4>Bypass of foregut secreted factors promoting insulin resistance is hypothesized to be one of the mechanisms by which resolution of type 2 diabetes (T2D) follows roux-en-y gastric bypass (GBP) surgery.<h4>Aim</h4>To identify insulin resistance-associated proteins and metabolites which decrease more after GBP than after sleeve gastrectomy (SG) prior to diabetes remission.<h4>Methods</h4>Fasting plasma from 15 subjects with T2D undergoing GBP or SG was analyzed by proteomic and metabolomic methods 3 days before and 3 days after surgery. Subjects were matched for age, BMI, metformin therapy and glycemic control. Insulin resistance was calculated using homeostasis model assessment (HOMA-IR). For proteomics, samples were depleted of abundant plasma proteins, digested with tryp"],"journal":["PloS one"],"pagination":["e96489"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4011803"],"repository":["biostudies-literature"],"pubmed_title":["Lower fetuin-A, retinol binding protein 4 and several metabolites after gastric bypass compared to sleeve gastrectomy in patients with type 2 diabetes."],"pmcid":["PMC4011803"],"pubmed_authors":["Middleditch M","Babor R","Yip S","Booth M","Beban G","Xu A","Jullig M","Smith G","Murphy R"],"additional_accession":[]},"is_claimable":false,"name":"Lower fetuin-A, retinol binding protein 4 and several metabolites after gastric bypass compared to sleeve gastrectomy in patients with type 2 diabetes.","description":"<h4>Background</h4>Bypass of foregut secreted factors promoting insulin resistance is hypothesized to be one of the mechanisms by which resolution of type 2 diabetes (T2D) follows roux-en-y gastric bypass (GBP) surgery.<h4>Aim</h4>To identify insulin resistance-associated proteins and metabolites which decrease more after GBP than after sleeve gastrectomy (SG) prior to diabetes remission.<h4>Methods</h4>Fasting plasma from 15 subjects with T2D undergoing GBP or SG was analyzed by proteomic and metabolomic methods 3 days before and 3 days after surgery. Subjects were matched for age, BMI, metformin therapy and glycemic control. Insulin resistance was calculated using homeostasis model assessment (HOMA-IR). For proteomics, samples were depleted of abundant plasma proteins, digested with tryp","dates":{"release":"2014-01-01T00:00:00Z","publication":"2014","modification":"2025-04-18T20:54:01.218Z","creation":"2019-03-26T23:24:39Z"},"accession":"S-EPMC4011803","cross_references":{"pubmed":["24800810"],"doi":["10.1371/journal.pone.0096489"]}}