{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Phesse TJ"],"funding":["Cancer Research UK","Worldwide Cancer Research","Biotechnology and Biological Sciences Research Council"],"pagination":["956-66"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4013513"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["21(6)"],"pubmed_abstract":["Recent studies have suggested that C-MYC may be an excellent therapeutic cancer target and a number of new agents targeting C-MYC are in preclinical development. Given most therapeutic regimes would combine C-MYC inhibition with genotoxic damage, it is important to assess the importance of C-MYC function for DNA damage signalling in vivo. In this study, we have conditionally deleted the c-Myc gene in the adult murine intestine and investigated the apoptotic response of intestinal enterocytes to DNA damage. Remarkably, c-Myc deletion completely abrogated the immediate wave of apoptosis following both ionizing irradiation and cisplatin treatment, recapitulating the phenotype of p53 deficiency in the intestine. Consistent with this, c-Myc-deficient intestinal enterocytes did not upregulate p5"],"journal":["Cell death and differentiation"],"pubmed_title":["Endogenous c-Myc is essential for p53-induced apoptosis in response to DNA damage in vivo."],"pmcid":["PMC4013513"],"funding_grant_id":["15937","18274","12481","10-0643"],"pubmed_authors":["Sansom OJ","Pearson H","Clarke AR","Vousden KH","Ridgway RA","Vassilev LT","Myant KB","Muncan V","Sears R","Phesse TJ","Cole AM","van den Brink GR"],"additional_accession":[]},"is_claimable":false,"name":"Endogenous c-Myc is essential for p53-induced apoptosis in response to DNA damage in vivo.","description":"Recent studies have suggested that C-MYC may be an excellent therapeutic cancer target and a number of new agents targeting C-MYC are in preclinical development. Given most therapeutic regimes would combine C-MYC inhibition with genotoxic damage, it is important to assess the importance of C-MYC function for DNA damage signalling in vivo. In this study, we have conditionally deleted the c-Myc gene in the adult murine intestine and investigated the apoptotic response of intestinal enterocytes to DNA damage. Remarkably, c-Myc deletion completely abrogated the immediate wave of apoptosis following both ionizing irradiation and cisplatin treatment, recapitulating the phenotype of p53 deficiency in the intestine. Consistent with this, c-Myc-deficient intestinal enterocytes did not upregulate p5","dates":{"release":"2014-01-01T00:00:00Z","publication":"2014 Jun","modification":"2025-04-05T13:37:42.073Z","creation":"2019-03-27T01:27:46Z"},"accession":"S-EPMC4013513","cross_references":{"pubmed":["24583641"],"doi":["10.1038/cdd.2014.15"]}}