biostudies-literatureUnknown49(5)Uemura N<h4>Background</h4>Low-dose aspirin is widely used for the prevention of cardiovascular events. The prevalence of gastroduodenal injuries and the risk factor profile including gastroprotective drug therapy needs to be clarified in Japanese patients taking daily aspirin for cardioprotection.<h4>Methods</h4>This Management of Aspirin-induced Gastro-Intestinal Complications (MAGIC) study was conducted with a prospective nationwide, multicenter, real-world registry of Japanese patients at high-risk of cardiovascular diseases who were taking regular aspirin (75-325 mg) for 1 month or more. All patients underwent endoscopic examination for detection of gastroduodenal ulcer and mucosal erosion. The risk factor profiles including the concurrent drug therapy were compared for those patients with gaJournal of gastroenterology814-24https://www.ebi.ac.uk/biostudies/studies/S-EPMC4019829biostudies-literatureRisk factor profiles, drug usage, and prevalence of aspirin-associated gastroduodenal injuries among high-risk cardiovascular Japanese patients: the results from the MAGIC study.PMC4019829Sugano KOsawa SNakagawa KHosoda SShimaoka SMutoh TKarasumaru HKawamura OOofuji YOzaki YMiyazaki YCardiology YSOnitake TOno SKatanuma AWatanabe EKudo TUchizono MYamagata MAsakura KToko TOgata TWatanabe HMatsuda AOsawa HKani KWatanabe KTsukuda YDoi TEguchi KYane KHosokawa MMitsui SHashimoto AYamazaki KChiku MKawai TFuruta TYamada MOoiwa HSagihara NTakekawa HOhtsubo MFuruta KTaguchi YArimura YOrigasa HDaimon YKuroda NSimizu YHosokawa ASaito HYamaoka YFurukawa STsuji AMatsuhashi NUemura YAsano MKuwabara YSasaki MOkimoto TSatoh HEbata ASatoh KSaifuku YTakamaru HSato YShimoyama YImaizumi TOka TSatoh SIkuma MUehara MHashimoto MSaitoh MKaneko YMurayama TIguchi YMiyamoto NNakano MImamura TKohya TNomura MOhta HNakano ASato TMatsuo TMatsushima MUchiyama SUchiyama TTakao MYamashita KMatsushima STatsugami MTakagi SSarai MMine TKusumoto KShirai TYakabi KTanimura MSugiyama TOgasawara HChiba TNeishi YMiki MAkaiwa YWada YShirai KOkuda HHoshide SUsami HMaeda MHirayama TTominaga KIkeda YHashimoto STNakamura MShisido TOkuda TMurasaki KUeno SMikami TTanuma TOsanai MShimpo MKanisawa YTakeuchi TOimatsu HWada MSuzuki AChujyou CBokura HKin TKurita ATajima AMatsuki ANakamura SMatsubara HTamura ASuzuki RHayashi YSuzuki TSuzuki MUeda ASakata TImagawa SSugita MSugawara NSakata YSuzuki HHayashi NHojo YMurakami HYagi HNagai TSako KImagawa HHirasawa TKiyonaga KWatanabe TOkazaki OTomita YOgura RTsuchihashi KNojima SHarada NKomaba FTanabe TYamauchi HMaruyama HHayasi TMiyazaki TMaruyama KKasai HOkubo SKoganezawa SMAGIC Study GroupSawada SIshio NShiratori YKusano MKoshiyama TOhtsuki TOba SYonehara TTashiro KFukasawa MSasai TKashiwabawa SShimada KIkegami TTakeuti KMatsui TTooi SShinohara YHiroe MAkiyama JHorinaka SSakakura KChinen KMiyauchi HYamanaka TKuwayama NImai HHirai TNiihara TGotou DAmano YNishino MMotoe JTsukahara KHiramatsu HIshimori NNishi KMukoujima TNioh TKoike JIijima KShiojima IYonezawa KHigaki TYokoyama SHigaki SHamada HKimura TKuwahara TSanomura YShima HAkazawa HHirono SHamada RNaono SKimura KTagusari OYonezawa HMiura TShibata TTanaka TYoshida DOguro HKubo KHara HTanaka KMasuda YKozuma KYawata AKazuno YYoshida SIshii KOkamoto KYoshida TKawashima JIshibashi YUtsumi ANozawa TShiotani AYoshida KOkamoto YKannbara TSouma TKondo TTokuyama TFukuda AArai MKono KNamba HYokoyama AMiyagi NHibi KMayumi KIwade KShimoaki HKinouchi HKanke KKobayashi TAkamatsu TTogashi NIto MFujii NGoto SIto SFujimi ATakano HHibi TKasahara KKobayashi AMatsumae MKoshida RIsida SSatou KAoyama TKotoku MTakamura AGoto ANishikawa MYamamoto KHoshino TIwamoto JYamamoto HMuto HAjibe HYabe AYamamoto THorita YNakashima HShindo SYoshioka KHokari RSakamoto CFurumoto TTanahashi JMannami TOrihara TIsobe SKokawa AYamamoto YHanaoka RKanemaru KNishimori HEndo SHirata IShimoda RUemura NShimamoto KHiraishi HOhsuzu FTakashima STakahashi THasegawa HYamaguchi SToyoshima SKato MKato NTachi KMizuno SMurata MTakahashi NKunimoto SOosawa MTakahashi KHosaka HMatsumoto STakeda NMatsumoto TTakeda MIshikawa SMiyake KMizutani KIshikawa JShida HMihara BTakigami MIshimura KIshimaru SOkada YMihara TKanamori SKitamura SKameyama TArao KImoto ISeo YUetsuka YNakagawara JfalseRisk factor profiles, drug usage, and prevalence of aspirin-associated gastroduodenal injuries among high-risk cardiovascular Japanese patients: the results from the MAGIC study.<h4>Background</h4>Low-dose aspirin is widely used for the prevention of cardiovascular events. The prevalence of gastroduodenal injuries and the risk factor profile including gastroprotective drug therapy needs to be clarified in Japanese patients taking daily aspirin for cardioprotection.<h4>Methods</h4>This Management of Aspirin-induced Gastro-Intestinal Complications (MAGIC) study was conducted with a prospective nationwide, multicenter, real-world registry of Japanese patients at high-risk of cardiovascular diseases who were taking regular aspirin (75-325 mg) for 1 month or more. All patients underwent endoscopic examination for detection of gastroduodenal ulcer and mucosal erosion. The risk factor profiles including the concurrent drug therapy were compared for those patients with ga2014-01-01T00:00:00Z2014 May2025-04-04T22:38:37.595Z2019-03-27T01:28:08ZS-EPMC40198292375451210.1007/s00535-013-0839-5