{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Chatzigeorgiou M"],"funding":["Medical Research Council"],"pagination":["95-99"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4021456"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["494(7435)"],"pubmed_abstract":["Transmembrane channel-like (TMC) genes encode a broadly conserved family of multipass integral membrane proteins in animals. Human TMC1 and TMC2 genes are linked to human deafness and required for hair-cell mechanotransduction; however, the molecular functions of these and other TMC proteins have not been determined. Here we show that the Caenorhabditis elegans tmc-1 gene encodes a sodium sensor that functions specifically in salt taste chemosensation. tmc-1 is expressed in the ASH polymodal avoidance neurons, where it is required for salt-evoked neuronal activity and behavioural avoidance of high concentrations of NaCl. However, tmc-1 has no effect on responses to other stimuli sensed by the ASH neurons including high osmolarity and chemical repellents, indicating a specific role in salt "],"journal":["Nature"],"pubmed_title":["tmc-1 encodes a sodium-sensitive channel required for salt chemosensation in C. elegans."],"pmcid":["PMC4021456"],"funding_grant_id":["MC_U105185857"],"pubmed_authors":["Bang S","Hwang SW","Schafer WR","Chatzigeorgiou M"],"additional_accession":[]},"is_claimable":false,"name":"tmc-1 encodes a sodium-sensitive channel required for salt chemosensation in C. elegans.","description":"Transmembrane channel-like (TMC) genes encode a broadly conserved family of multipass integral membrane proteins in animals. Human TMC1 and TMC2 genes are linked to human deafness and required for hair-cell mechanotransduction; however, the molecular functions of these and other TMC proteins have not been determined. Here we show that the Caenorhabditis elegans tmc-1 gene encodes a sodium sensor that functions specifically in salt taste chemosensation. tmc-1 is expressed in the ASH polymodal avoidance neurons, where it is required for salt-evoked neuronal activity and behavioural avoidance of high concentrations of NaCl. However, tmc-1 has no effect on responses to other stimuli sensed by the ASH neurons including high osmolarity and chemical repellents, indicating a specific role in salt ","dates":{"release":"2013-01-01T00:00:00Z","publication":"2013 Feb","modification":"2025-04-05T10:38:15.249Z","creation":"2019-03-27T01:28:14Z"},"accession":"S-EPMC4021456","cross_references":{"pubmed":["23364694"],"doi":["10.1038/nature11845"]}}