biostudies-literatureMatsuzaki MEconomic and Social Research CouncilNCATS NIH HHSMedical Research CouncilWellcome Trust1450-9https://www.ebi.ac.uk/biostudies/studies/S-EPMC4021785biostudies-literatureUnknown99(6)<h4>Background</h4>Undernutrition and physical inactivity are both associated with lower bone mass.<h4>Objective</h4>This study aimed to investigate the combined effects of early-life undernutrition and urbanized lifestyles in later life on bone mass accrual in young adults from a rural community in India that is undergoing rapid socioeconomic development.<h4>Design</h4>This was a prospective cohort study of participants of the Hyderabad Nutrition Trial (1987-1990), which offered balanced protein-calorie supplementation to pregnant women and preschool children younger than 6 y in the intervention villages. The 2009-2010 follow-up study collected data on current anthropometric measures, bone mineral density (BMD) measured by dual-energy X-ray absorptiometry, blood samples, diet, physical acThe American journal of clinical nutritionLife-course determinants of bone mass in young adults from a transitional rural community in India: the Andhra Pradesh Children and Parents Study (APCAPS).PMC4021785084674MC_UU_12013/1UL1 TR001425ES/G040923/1Sullivan RViljakainen HMatsuzaki MKuper HEbrahim SKinra SKulkarni BBen-Shlomo YTaylor AEDavey Smith GRadhakrishna KVPloubidis GBPrabhakaran DTobias JHWells JCBowen LfalseLife-course determinants of bone mass in young adults from a transitional rural community in India: the Andhra Pradesh Children and Parents Study (APCAPS).<h4>Background</h4>Undernutrition and physical inactivity are both associated with lower bone mass.<h4>Objective</h4>This study aimed to investigate the combined effects of early-life undernutrition and urbanized lifestyles in later life on bone mass accrual in young adults from a rural community in India that is undergoing rapid socioeconomic development.<h4>Design</h4>This was a prospective cohort study of participants of the Hyderabad Nutrition Trial (1987-1990), which offered balanced protein-calorie supplementation to pregnant women and preschool children younger than 6 y in the intervention villages. The 2009-2010 follow-up study collected data on current anthropometric measures, bone mineral density (BMD) measured by dual-energy X-ray absorptiometry, blood samples, diet, physical ac2014-01-01T00:00:00Z2014 Jun2025-04-19T02:41:04.051Z2019-03-27T01:28:16ZS-EPMC40217852469589810.3945/ajcn.113.068791