biostudies-literatureZheng YNIDDK NIH HHSNHGRI NIH HHSPHS HHS1470-8https://www.ebi.ac.uk/biostudies/studies/S-EPMC4021786biostudies-literatureUnknown99(6)<h4>Background</h4>Effects of alcohol consumption on health and disease are complex and involve a number of cellular and metabolic processes.<h4>Objective</h4>We examined the association between alcohol consumption habits and metabolomic profiles.<h4>Design</h4>We conducted a cross-sectional study to explore the association of alcohol consumption habits measured by using a questionnaire with serum metabolites measured by using untargeted mass spectrometry in 1977 African Americans from the Jackson field center in the Atherosclerosis Risk in Communities Study. The whole sample was split into a discovery set (n = 1500) and a replication set (n = 477). Alcohol consumption habits were treated as an ordinal variable, with nondrinkers as the reference group and quartiles of current drinkers as oThe American journal of clinical nutritionMetabolomic patterns and alcohol consumption in African Americans in the Atherosclerosis Risk in Communities Study.PMC4021786HHSN268201100006CHHSN268201100005CHHSN268201100008CHHSN268201100007CHHSN268201100009CHHSN268201100011CHHSN268201100010C3U01HG004402-02S15K01DK082729-04HHSN268201100012CSteffen LMZheng YYu BAlexander DBoerwinkle ENettleton JAfalseMetabolomic patterns and alcohol consumption in African Americans in the Atherosclerosis Risk in Communities Study.<h4>Background</h4>Effects of alcohol consumption on health and disease are complex and involve a number of cellular and metabolic processes.<h4>Objective</h4>We examined the association between alcohol consumption habits and metabolomic profiles.<h4>Design</h4>We conducted a cross-sectional study to explore the association of alcohol consumption habits measured by using a questionnaire with serum metabolites measured by using untargeted mass spectrometry in 1977 African Americans from the Jackson field center in the Atherosclerosis Risk in Communities Study. The whole sample was split into a discovery set (n = 1500) and a replication set (n = 477). Alcohol consumption habits were treated as an ordinal variable, with nondrinkers as the reference group and quartiles of current drinkers as o2014-01-01T00:00:00Z2014 Jun2025-04-19T02:41:05.149Z2019-03-27T01:28:16ZS-EPMC40217862476097610.3945/ajcn.113.074070