{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["12"],"submitter":["Lopatina T"],"pubmed_abstract":["<h4>Background</h4>Several studies demonstrate the role of adipose mesenchymal stem cells (ASCs) in angiogenesis. The angiogenic mechanism has been ascribed to paracrine factors since these cells secrete a plenty of signal molecules and growth factors. Recently it has been suggested that besides soluble factors, extracellular vesicles (EVs) that include exosomes and microvesicles may play a major role in cell-to-cell communication. It has been shown that EVs are implicated in the angiogenic process.<h4>Results</h4>Herein we studied whether EVs released by ASCs may mediate the angiogenic activity of these cells. Our results demonstrated that ASC-derived EVs induced in vitro vessel-like structure formation by human microvascular endothelial cells (HMEC). EV-stimulated HMEC when injected subc"],"journal":["Cell communication and signaling : CCS"],"pagination":["26"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4022079"],"repository":["biostudies-literature"],"pubmed_title":["Platelet-derived growth factor regulates the secretion of extracellular vesicles by adipose mesenchymal stem cells and enhances their angiogenic potential."],"pmcid":["PMC4022079"],"pubmed_authors":["Kalinina N","Bruno S","Porta M","Lopatina T","Camussi G","Tetta C"],"additional_accession":[]},"is_claimable":false,"name":"Platelet-derived growth factor regulates the secretion of extracellular vesicles by adipose mesenchymal stem cells and enhances their angiogenic potential.","description":"<h4>Background</h4>Several studies demonstrate the role of adipose mesenchymal stem cells (ASCs) in angiogenesis. The angiogenic mechanism has been ascribed to paracrine factors since these cells secrete a plenty of signal molecules and growth factors. Recently it has been suggested that besides soluble factors, extracellular vesicles (EVs) that include exosomes and microvesicles may play a major role in cell-to-cell communication. It has been shown that EVs are implicated in the angiogenic process.<h4>Results</h4>Herein we studied whether EVs released by ASCs may mediate the angiogenic activity of these cells. Our results demonstrated that ASC-derived EVs induced in vitro vessel-like structure formation by human microvascular endothelial cells (HMEC). EV-stimulated HMEC when injected subc","dates":{"release":"2014-01-01T00:00:00Z","publication":"2014 Apr","modification":"2025-04-04T21:52:54.883Z","creation":"2019-03-27T01:28:17Z"},"accession":"S-EPMC4022079","cross_references":{"pubmed":["24725987"],"doi":["10.1186/1478-811X-12-26"]}}