{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["111(19)"],"submitter":["Ko D"],"pubmed_abstract":["Cytokinins are phytohormones that induce cytokinesis and are essential for diverse developmental and physiological processes in plants. Cytokinins of the trans-zeatin type are mainly synthesized in root vasculature and transported to the shoot, where they regulate shoot growth. However, the mechanism of long-distance transport of cytokinin was hitherto unknown. Here, we report that the Arabidopsis ATP-binding cassette (ABC) transporter subfamily G14 (AtABCG14) is mainly expressed in roots and plays a major role in delivering cytokinins to the shoot. Loss of AtABCG14 expression resulted in severe shoot growth retardation, which was rescued by exogenous trans-zeatin application. Cytokinin content was decreased in the shoots of atabcg14 plants and increased in the roots, with consistent chang"],"journal":["Proceedings of the National Academy of Sciences of the United States of America"],"pagination":["7150-5"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4024864"],"repository":["biostudies-literature"],"pubmed_title":["Arabidopsis ABCG14 is essential for the root-to-shoot translocation of cytokinin."],"pmcid":["PMC4024864"],"pubmed_authors":["Kiba T","Song WY","Martinoia E","Park J","Kwon M","Kim KY","Ko D","Sakakibara H","Kojima M","Do J","Endler A","Lee Y","Kang J"],"additional_accession":[]},"is_claimable":false,"name":"Arabidopsis ABCG14 is essential for the root-to-shoot translocation of cytokinin.","description":"Cytokinins are phytohormones that induce cytokinesis and are essential for diverse developmental and physiological processes in plants. Cytokinins of the trans-zeatin type are mainly synthesized in root vasculature and transported to the shoot, where they regulate shoot growth. However, the mechanism of long-distance transport of cytokinin was hitherto unknown. Here, we report that the Arabidopsis ATP-binding cassette (ABC) transporter subfamily G14 (AtABCG14) is mainly expressed in roots and plays a major role in delivering cytokinins to the shoot. Loss of AtABCG14 expression resulted in severe shoot growth retardation, which was rescued by exogenous trans-zeatin application. Cytokinin content was decreased in the shoots of atabcg14 plants and increased in the roots, with consistent chang","dates":{"release":"2014-01-01T00:00:00Z","publication":"2014 May","modification":"2025-04-05T13:37:34.241Z","creation":"2019-03-27T01:28:26Z"},"accession":"S-EPMC4024864","cross_references":{"pubmed":["24778257"],"doi":["10.1073/pnas.1321519111"]}}